White-Matter Hyperintensities and Lacunar Infarcts Are Associated with an Increased Risk of Alzheimer's Disease in the Elderly in China
White-Matter Hyperintensities and Lacunar Infarcts Are Associated with an Increased Risk of Alzheimer's Disease in the Elderly in China
复制标题
DOI：
10.3988/jcn.2019.15.1.46
复制
发表时间：
2018-12
期刊：
影响因子：
--
通讯作者：
S. Ye;Shuyang Dong;Jun Tan;Le Chen;Hai Yang;Y. Chen;Zeyan Peng;Ying-chao Huo;Juan Liu;Mingshan Tang;Yafei Li;Huadong Zhou;Yong Tao
中科院分区：
文献类型：
--
作者：
S. Ye;Shuyang Dong;Jun Tan;Le Chen;Hai Yang;Y. Chen;Zeyan Peng;Ying-chao Huo;Juan Liu;Mingshan Tang;Yafei Li;Huadong Zhou;Yong Tao
背景和目的本研究探讨了中国老年人群中白质高信号（WMH）和腔隙性梗死（LI）与阿尔茨海默病（AD）风险的关系。方法对认知功能正常的老年人进行MRI检查，并随访5年。WMH分为轻度、中度和重度，LI分为少数LI（1 ~ 3）和多LI（≥4）。认知功能采用简易精神状态检查和日常生活活动量表进行评估。结果在2,626名受试者中，357名在5年随访期结束时发展为AD。在调整年龄和其他潜在混杂因素后，与既无WMH也无LI相比，仅WMH、仅LI、WMH和LI均与AD发生风险增加相关。与无WMH相比，中度和重度WMH与AD发生风险增加相关。此外，与没有LI的患者相比，有许多LI的患者发生AD的风险增加。结论中度或重度WMH和许多LI与AD发生风险增加相关，当WMH和LI同时存在时，这一点尤其明显。
Background and Purpose This study investigated the contribution of white-matter hyperintensities (WMH) and lacunar infarcts (LI) to the risk of Alzheimer's disease (AD) in an elderly cohort in China. Methods Older adults who were initially cognitively normal were examined with MRI at baseline, and followed for 5 years. WMH were classified as mild, moderate, or severe, and LI were classified into a few LI (1 to 3) or many LI (≥4). Cognitive function was assessed using the Mini Mental State Examination and the Activities of Daily Living scale. Results Among the 2,626 subjects, 357 developed AD by the end of the 5-year follow-up period. After adjusting for age and other potential confounders, having only WMH, having only LI, and having both WMH and LI were associated with an increased risk of developing AD compared with having neither WMH nor LI. Moderate and severe WMH were associated with an increased risk of developing AD compared with no WMH. Furthermore, patients with many LI had an increased risk of developing AD compared with no LI. Conclusions Having moderate or severe WMH and many LI were associated with an increased risk of developing AD, with this being particularly striking when both WMH and LI were present.