Response to pneumococcal vaccine in interstitial lung disease patients: Influence of systemic immunosuppressive treatment
Response to pneumococcal vaccine in interstitial lung disease patients: Influence of systemic immunosuppressive treatment
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DOI：
10.1016/j.vaccine.2018.06.062
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发表时间：
2018-08-09
期刊：
影响因子：
5.5
通讯作者：
Takahashi, Hiroki
中科院分区：
文献类型：
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作者：
Kuronum, Koji;Honda, Hiroyuki;Takahashi, Hiroki
背景资料：间质性肺疾病（ILD）是严重的呼吸系统疾病，ILD患者使用皮质类固醇和免疫抑制剂治疗。然而，目前还不清楚这些药物是否会影响肺炎球菌疫苗的反应。Objectives：我们研究了肺炎球菌疫苗（PPSV 23和PCV 13）在ILD患者接受免疫抑制治疗的免疫原性。在接种前和接种后4-8周收集血清。血清型特异性免疫球蛋白G（IgG）浓度对肺炎球菌血清型19 F测定ELISA。结果：血清型19 F的IgG浓度增加，在所有组的疫苗。PCV 13和PSV 23均诱导首次免疫患者的IgG浓度。ILD组的缓解率与接受皮质类固醇治疗的ILD组的缓解率相当。只有接受免疫抑制治疗的特发性肺纤维化患者的反应明显较低。(C)2018爱思唯尔有限公司版权所有
Background: Interstitial lung diseases (ILD) are severe respiratory diseases, and ILD patients are treated with corticosteroid and immunosuppressive agents. However, it is unclear whether these medications influence the response of pneumococcal vaccine.Objectives: We examined the immunogenicity of pneumococcal vaccines (PPSV23 and PCV13) in ILD patients undergoing immunosuppressive treatment.Methods: ILD patients who were regularly followed at the outpatient clinic were enrolled. Sera were collected before and 4-8 weeks after vaccination. Serotype-specific immunoglobulin G (IgG) concentrations against pneumococcal serotype 19F were measured by ELISA.Results: IgG concentrations to serotype 19F were increased in all groups in response to the vaccine. Both PCV13 and PPSV23 induced IgG concentrations in patients immunized for the first time. Response rates for the ILD group were comparable with those for the ILD group undergoing corticosteroid therapy. Only idiopathic pulmonary fibrosis patients undergoing immunosuppressive therapy had a significantly lower response. (C) 2018 Elsevier Ltd. All rights reserved.