Characterization of synovial fluid cytokine profiles in chronic meniscal tear of the knee
Characterization of synovial fluid cytokine profiles in chronic meniscal tear of the knee
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DOI：
10.1002/jor.23272
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发表时间：
2017-02-01
影响因子：
2.8
通讯作者：
Torsello, Antonio
中科院分区：
文献类型：
--
作者：
Bigoni, Marco;Turati, Marco;Torsello, Antonio
研究了慢性半月板撕裂患者滑液中促炎性和抗炎性细胞因子的浓度。膝关节损伤后24-48小时通常报道急性炎症反应，但文献中可获得的最大数据体涉及前交叉韧带损伤，关于慢性半月板撕裂的膝关节滑液中可溶性因子平衡的信息很少。69例半月板撕裂患者（男46例，女23例）发生时间超过3个月。根据关节镜检查的软骨完整性评估，将患者分为以下两组：(i)无软骨损伤（n=18）；（ii） I ~ ii级软骨损伤（n=15）；（iii）三级至四级软骨损伤（n=37）。在所有组中，IL-10和炎症细胞因子IL-6、TNF-和IL-8的水平均高于未受影响人群；相比之下，IL-1ra和IL-1水平明显降低。有趣的是，女性患者的IL-6水平高于男性患者。细胞因子水平与软骨损伤程度无关。IL-6、IL-1ra水平与IL-1呈正相关，与TNF-负相关。有趣的是，IL-1和TNF-水平呈负相关。我们的数据表明，在半月板创伤的慢性期，促炎细胞因子（IL-6、IL-8和TNF-）水平升高。这种促炎状态从最初损伤到几个月后一直维持在关节中，可能是阻碍软骨再生的关键因素。(c) 2016年骨科研究会。Wiley期刊公司出版。[J]中华骨科杂志，2017,35(5):334 -346。
Concentrations of pro- and anti-inflammatory cytokines in synovial fluid samples collected from patients with chronic meniscal tears were investigated. An acute inflammatory response is generally reported 24-48h after knee injury, but the largest body of data available in literature concerns anterior cruciate ligament injury and very little information is available about the balance of soluble factors in the synovial fluid of knees with chronic meniscal tears. Sixty-nine patients (46 males and 23 females) with meniscal tear that occurred more than 3 months earlier were enrolled. According to cartilage integrity assessment by arthroscopic examination, patients were assigned to one of the following groups: (i) no chondral damage (n=18); (ii) chondral damage graded from I to II (n=15); and (iii) chondral damage graded from III to IV (n=37). In all groups, levels of IL-10 and inflammatory cytokines IL-6, TNF-, and IL-8 where greater compared with those reported in the intact population; by contrast, levels of IL-1ra and IL-1 were significantly lower. Interestingly, IL-6 levels were higher in female than male patients. Cytokine levels did not correlate with degree of chondral damage. IL-6 and IL-1ra levels positively correlated with IL-1, and negatively correlated with TNF-. Interestingly, levels of IL-1 and TNF- were inversely correlated. Our data demonstrate increased levels of pro-inflammatory cytokines (IL-6, IL-8, and TNF-) in the chronic phase of meniscal trauma. This pro-inflammatory state is maintained in the joint from the time of initial injury to several months later and could be a key factor in hampering cartilage regeneration. (c) 2016 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 35:340-346, 2017.