Suboptimal medication adherence in Parkinson's disease
Suboptimal medication adherence in Parkinson's disease
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DOI：
10.1002/mds.20602
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发表时间：
2005-11-01
影响因子：
8.6
通讯作者：
Grosset, DG
中科院分区：
文献类型：
--
作者：
Grosset, KA;Bone, I;Grosset, DG
在许多疾病领域，患者服用的药物少于处方药物，但帕金森病（PD）治疗依从性不佳的证据有限。使用电子监测（MEMS; Aardex，Zug，Switzerland）进行了一项为期3个月的抗帕金森病药物单中心观察性研究。在68例患者中，6例拒绝，8例退出，剩下54例患者（服用117种制剂）有可用数据。依从性较差与年龄较小、每天服用更多抗帕金森病药片、抑郁评分较高和生活质量较差显着相关。在54例可评价患者中，11例（20%）的平均总依从性低于80%（用药不足），43例（80%）的平均总依从性超过80%（依从性满意）。未充分使用者的总依从性中位数为65%（四分位距，37-74），而满意依从性组为98%（四分位距，93-102）。用药不足者（中位数，11%;四分位数范围，2-20）和依从性满意者（中位数，25%;四分位数范围，11-73）的时间依从性（在正确的时间间隔内服用的剂量数）均较差。总之，依从性较差与年龄较小，抑郁症，每天更多的片剂，以及五分之一的PD患者未充分使用药物有关。考虑药物治疗依从性对PD的管理有影响。(c)2005年，任上海市人民政府副市长。
Patients take less medication than prescribed in many disease areas but evidence for suboptimal therapy adherence in Parkinson's disease (PD) is limited. A single-center observational study of antiparkinsonian medication was undertaken using electronic monitoring (MEMS; Aardex, Zug, Switzerland) over 3 months. Of 68 patients approached, 6 declined and 8 dropped out, leaving 54 patients (taking 117 preparations) with available data. Poorer compliance was associated significantly with younger age, with taking more antiparkinsonian tablets per day, with higher depression scores, and with poorer quality of life. Of the 54 evaluable patients, 11 (20%) had average total compliance of under 80% (underusers) and 43 (80%) had average total compliance of over 80% (satisfactory adherence). Underusers had median total compliance of 65% (interquartile range, 37-74) versus 98% (interquartile range, 93-102) in the satisfactory adherence group. Timing compliance (number of doses taken in the correct time interval) was poor in both underusers (median, 11%; interquartile range, 2-20) and those with satisfactory adherence (median, 25%; interquartile range, 11-73). In conclusion, poorer compliance is associated with younger age, depression, and more tablets per day, and one-fifth of PD patients underuse medication. Consideration of drug therapy adherence has implications in the management of PD. (c) 2005 Movement Disorder Society.