NEUROPATHIC PAIN AND INJURED NERVE - PERIPHERAL MECHANISMS
NEUROPATHIC PAIN AND INJURED NERVE - PERIPHERAL MECHANISMS
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DOI：
10.1093/oxfordjournals.bmb.a072496
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发表时间：
1991-07-01
影响因子：
6.7
通讯作者：
DEVOR, M
中科院分区：
文献类型：
--
作者：
DEVOR, M
感觉神经轴突的损伤通常会产生矛盾的影响，导致积极的感觉障碍、感觉异常和慢性神经性疼痛。这些症状至少可以从受损感觉神经元的电兴奋性发生的病理生理变化方面得到部分理解。这些变化导致异常持续和诱发放电的产生，或者起源于各种异位神经起搏器部位。许多推荐用于神经病理性疼痛的最有效的治疗方法都是通过减少这种异位神经放电来起作用的。
Injury to sensory axons often has the paradoxical effect of inducing positive sensory disturbances; paraesthesias and chronic neuropathic pain. Such symptoms can be at least partially understood in terms of pathophysiological changes that occur in the electrical excitability of the injured sensory neuron. These changes result in the generation of an abnormal ongoing and evoked discharge, originating, alternatively, at various ectopic neural pacemaker sites. Many of the most effective therapeutic modalities recommended for neuropathic pain act by reducing this ectopic neural discharge.