Collaboration as a Key to Advance Capabilities for Earth-Abundant Metal Catalysis
Collaboration as a Key to Advance Capabilities for Earth-Abundant Metal Catalysis
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DOI：
10.1021/acs.oprd.3c00025
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发表时间：
2023-03
期刊：
影响因子：
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通讯作者：
P. Chirik;K. Engle;E. Simmons;S. Wisniewski
中科院分区：
文献类型：
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作者：
P. Chirik;K. Engle;E. Simmons;S. Wisniewski
地球丰富的金属（EAM）催化可以在制药行业的可持续性和成本改善方面产生深远的影响，从取代钯等贵金属以及利用第一行金属的差异反应性，允许新的转化，以实现更有效的临床候选人路线。本文描述了在布里斯托迈尔斯施贵宝的工艺组内建立这些能力的策略，以及建立反应筛选平台的总体计划，展示了可扩展性，并增加了对反应和催化剂活化的机理理解。介绍了利用镍、钴和铁的催化转化的发展，同时强调了与内部和外部团体合作的重要性，以推进EAM催化并影响我们的产品组合。与第一行过渡金属，包括EAM催化的实施，如成本，工艺质量强度，催化剂和配体的商业可用性的指标，工作的挑战和好处进行了讨论。
Earth-abundant metal (EAM) catalysis can have profound impact in the pharmaceutical industry in terms of sustainability and cost improvements from replacing precious metals like palladium as well as harnessing the differential reactivity of first-row metals that allows for novel transformations to enable more efficient routes to clinical candidates. The strategy for building these capabilities within the process group at Bristol Myers Squibb is described herein, with the general plan of building a reaction screening platform, demonstrating scalability, and increasing mechanistic understanding of the reaction and catalyst activation. The development of catalytic transformations utilizing nickel, cobalt, and iron is described while highlighting the importance of collaboration with internal and external groups to advance EAM catalysis and impact our portfolio. The challenges and benefits of working with first-row transition metals, including metrics for the implementation of EAM catalysis, such as cost, process mass intensity, and commercial availability of catalysts and ligands, are discussed.