Trends in the Incidence of Japanese Spotted Fever in Japan: A Nationwide, Two-Decade Observational Study from 2001-2020
Trends in the Incidence of Japanese Spotted Fever in Japan: A Nationwide, Two-Decade Observational Study from 2001-2020
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DOI：
10.4269/ajtmh.22-0487
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发表时间：
2023-04-01
影响因子：
3.3
通讯作者：
Otsuka, Fumio
中科院分区：
文献类型：
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作者：
Otsuka, Yuki;Hagiya, Hideharu;Otsuka, Fumio
蜱传疾病（TBD）在全球范围内的传播已成为一个公共卫生问题。因此，本研究旨在阐明日本斑疹热（JSF）（日本最流行的TBD之一）发病率的趋势。每周传染病报告用于计算JSF的年发病率（AIR）。数据按年龄和性别分层，并进行联合点回归分析，以估计年度百分比变化（APC）。在47个都道府县之间对AIR和APC进行了地理比较。从2001年到2020年，共观察到3，453例JSF病例。2001年每10万人口空气污染指数为0. 03，2020年上升约10倍至0. 33。研究期间的平均APC（AAPC）为12.3%（95% CI：10.7-13.9）。按年龄组划分，JSF的发病率在老年人群中增长更快：≥ 65岁人群为11.5%（95%CI：10.1-12.9），< 50岁人群为8.9%（95%CI：6.4-11.5）。虽然在过去的二十年中，位于日本西南部和太平洋沿岸的气候温暖地区的空气含量较高，但在日本东部较冷的地区，AAPC的增加是显着的。在日本，JSF的发病率持续上升，特别是在老年人群和东部地区，那里以前没有诊断出这种疾病。
The worldwide spread of tick-borne diseases (TBDs) has become a public health concern. Therefore, this study aimed to clarify trends in the incidence of Japanese spotted fever (JSF), one of Japan's most prevalent TBDs. Weekly infectious disease reports were used to calculate the annual incidence rates (AIRs) of JSF. Data were stratified by age and sex, and joinpoint regression analysis was performed to estimate the annual percentage change (APC). AIR and APC were geographically compared among the 47 prefectures. A total of 3,453 JSF cases were observed from 2001 to 2020. The AIR per 100,000 population was 0.03 in 2001, which increased approximately 10-fold to 0.33 in 2020. The average APC (AAPC) during the study period was 12.3% (95% CI: 10.7-13.9). By age group, the incidence of JSF increased more rapidly among the older population: 11.5% (95% CI: 10.1-12.9) in those aged >= 65 years and 8.9% (95% CI: 6.4-11.5) in those aged < 50 years. Although the AIR over the past two decades was higher in climatically warm regions located in southwestern Japan and on the Pacific coast, increases in the AAPC were notable in colder regions located in eastern Japan. The incidence of JSF continues to increase in Japan, especially among older popula-tions and in eastern prefectures, where the disease has not been previously diagnosed.