The role of gender in studies of ventricle enlargement in schizophrenia: a predominantly male effect.
The role of gender in studies of ventricle enlargement in schizophrenia: a predominantly male effect.
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性别在精神分裂症心室扩大研究中的作用：主要是男性效应。
DOI：
10.1176/ajp.147.10.1327
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发表时间：
1990
期刊：
影响因子：
--
通讯作者：
Andreasen,NC
中科院分区：
文献类型：
--
作者：
Flaum,M;Arndt,S;Andreasen,NC
作者实验室的两项先前报道的神经影像学研究表明，精神分裂症患者的侧脑室比正常对照组大。这种诊断效果几乎完全由男性受试者解释。本报告通过重新审查这些数据集和先前两项研究的数据集，进一步探讨了性别的作用。虽然性别诊断的影响没有得到证明，在四项研究中的三个男性精神分裂症患者的显着大于他们的对照组的心室，有女性受试者之间没有差异。一项研究表明了相反的效果，但这可能归因于一个非代表性的对照组。
Two previously reported neuroimaging studies from the authors' laboratory demonstrated larger lateral ventricles in schizophrenic patients than in normal control subjects. This diagnostic effect was accounted for almost entirely by the male subjects. In this report the role of gender is further explored through reexamining these data sets and those of two earlier studies. Although Gender by Diagnosis effects were not demonstrated, in three of the four studies male schizophrenic subjects had significantly larger ventricles than their control counterparts; there were no differences among the female subjects. One study suggested the opposite effect, but this may be attributable to a non-representative control group.