Modification of polyethersulfone membrane by grafting bovine serum albumin on the surface of polyethersulfone/poly(acrylonitrile-co-acrylic acid) blended membrane
Modification of polyethersulfone membrane by grafting bovine serum albumin on the surface of polyethersulfone/poly(acrylonitrile-co-acrylic acid) blended membrane
复制标题
聚醚砜/聚丙烯腈-丙烯酸共混膜表面接枝牛血清白蛋白对聚醚砜膜的改性
DOI：
10.1016/j.memsci.2008.12.008
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发表时间：
2009-03-05
影响因子：
9.5
通讯作者：
Zhao, Changsheng
中科院分区：
文献类型：
--
作者：
Fang, Baohong;Ling, Qiyao;Zhao, Changsheng
采用丙烯腈（AN）和丙烯酸（AA）共聚物对聚醚砜（PES）膜进行共混改性，并在PES膜表面接枝牛血清白蛋白（BSA）。采用旋涂法结合液-液相分离技术制备了聚醚砜（PES）和聚丙烯腈-丙烯酸（PAN-AA）共混膜。Micro BCA（TM）蛋白质分析、XPS和FTIR/ATR分析证实BSA成功地接枝到膜表面上。共聚物的预活化羧基和蛋白质的氨基有助于形成BSA-PES膜缀合物。在膜表面接枝BSA后，水接触角、蛋白吸附量和血小板粘附量均明显降低，膜的水通量明显增加。结果表明，改性后的聚醚砜膜的亲水性和血液相容性得到了改善。(c)2008 Elsevier B. V.保留所有权利。
Polyethersulfone (PES) membrane was modified by blending with a copolymer of acrylonitrile (AN) and acrylic acid (AA), followed by grafting bovine serum albumin (BSA) onto the surface of the membrane. The PES and PAN-AA blending membranes were prepared through spin coating coupled with a liquid-liquid phase separation technique. The Micro BCA (TM) protein assay, XPS and FTIR/ATR analysis confirmed that BSA was successfully grafted onto the surface of the membranes. The pre-activated carboxyl groups of the copolymer and the amino groups of the protein contributed to the formation of BSA-PES membrane conjugates. The water contact angle, protein adsorption and platelet adhesion were obviously decreased after grafting BSA onto the membrane surface, meanwhile the water flux of the membrane was significantly increased. All these results indicated that the hydrophilicity and blood compatibility of the modified PES membranes were improved. (c) 2008 Elsevier B.V. All rights reserved.