Xenotropic murine leukemia virus-related virus-associated chronic fatigue syndrome reveals a distinct inflammatory signature.
Xenotropic murine leukemia virus-related virus-associated chronic fatigue syndrome reveals a distinct inflammatory signature.
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发表时间：
2011-05
期刊：
影响因子：
2.3
通讯作者：
V. C. Lombardi;Kathryn S. Hagen;K. Hunter;John W. Diamond;J. Smith-Gagen;Wei Yang;J. Mikovits
中科院分区：
文献类型：
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作者：
V. C. Lombardi;Kathryn S. Hagen;K. Hunter;John W. Diamond;J. Smith-Gagen;Wei Yang;J. Mikovits
背景最近在慢性疲劳综合征（CFS）患者血液中鉴定出异嗜性小鼠白血病病毒相关病毒（XMRV），证实逆转录病毒可能在该疾病的病理学中起作用。了解免疫反应可能有助于更好地理解XMRV在该综合征中的作用。我们的目的是研究细胞因子和趋化因子在XMRV相关CFS中的反应。材料和方法使用Luminex多分析物分析技术，我们测量了XMRV感染CFS患者血浆中的细胞因子和趋化因子值，并将这些数据与健康对照组进行比较。使用基因表达模式分析套件和随机森林树分类算法进行分析。结果：本研究鉴定了10种细胞因子和趋化因子的特征，其以93%的特异性和96%的灵敏度正确地鉴定XMRV/CFS患者。结论这些数据首次显示了与XMRV/CFS相关的免疫学模式。
BACKGROUND The recent identification of xenotropic murine leukemia virus-related virus (XMRV) in the blood of patients with chronic fatigue syndrome (CFS) establishes that a retrovirus may play a role in the pathology in this disease. Knowledge of the immune response might lead to a better understanding of the role XMRV plays in this syndrome. Our objective was to investigate the cytokine and chemokine response in XMRV-associated CFS. MATERIALS AND METHODS Using Luminex multi-analyte profiling technology, we measured cytokine and chemokine values in the plasma of XMRV-infected CFS patients and compared these data to those of healthy controls. Analysis was performed using the Gene Expression Pattern Analysis Suite and the Random Forest tree classification algorithm. RESULTS This study identifies a signature of 10 cytokines and chemokines which correctly identifies XMRV/CFS patients with 93% specificity and 96% sensitivity. CONCLUSION These data show, for the first time, an immunological pattern associated with XMRV/CFS.