Synthesis, characterization, and in vitro release analysis of a novel glucan-based polymer carrier
Synthesis, characterization, and in vitro release analysis of a novel glucan-based polymer carrier
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新型葡聚糖基聚合物载体的合成、表征和体外释放分析
DOI：
10.1007/s00396-018-4354-3
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发表时间：
2018-06
影响因子：
2.4
通讯作者：
Gang Li
中科院分区：
文献类型：
--
作者：
Fang Yang;Huaxin Han;Hongxian Fan;Dan Xiao;Yuhuan Chen;Gang Li
A novel drug carrier was synthesized through grafting polymerization of water-insoluble glucan from cotton cellulose tailored and polyoxyethylene oxide (PEO). By changing the molar ratio of water-insoluble glucan and ethylene oxide (EO), glucan-g-PEO copolymers with different chain lengths of PEO can be obtained. The physicochemical characteristics of docetaxel (DTX)-loaded glucan-g-PEO such as micro-morphology, size, critical micelle concentration (CMC), and in vitro release of kinetic were investigated. In vitro release profiles of docetaxel (DTX)-loaded glucan-g-PEO meet first-order release kinetics via a mechanism of diffusion and polymer chain relaxation. Another significant result is that release rates of DTX can be also modulated by changing the chain lengths of the PEO segments.
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影响因子：
5.1
作者：
Wen-Chung Wu;Chi Huang;P. Liao
通讯作者：
Wen-Chung Wu;Chi Huang;P. Liao
由两亲性前药组装而成的还原敏感混合胶束，用于 DOX 和 DTX 的自我共传递与协同癌症治疗
DOI：
10.1016/j.colsurfb.2017.11.011
发表时间：
2018
期刊：
Colloids and Surfaces B: Biointerfaces
影响因子：
--
作者：
Wu Jilian;Zhang Huiyuan;Hu Xu;Liu Ruiling;Jiang Wei;Li Zhonghao;Luan Yuxia
通讯作者：
Luan Yuxia
影响因子：
5.1
作者：
Ching-Yi Chen;Yun-Chu Wang;Chi-Chiuan Hung
通讯作者：
Ching-Yi Chen;Yun-Chu Wang;Chi-Chiuan Hung
DOI：
10.1016/j.jconrel.2014.03.041
发表时间：
2014-10-10
期刊：
Journal of controlled release : official journal of the Controlled Release Society
影响因子：
--
作者：
Keller S;Wilson JT;Patilea GI;Kern HB;Convertine AJ;Stayton PS
通讯作者：
Stayton PS
负载多西他赛的 PEO-PPO-PCL/TPGS 混合胶束克服多药耐药性并增强抗肿瘤功效
DOI：
10.1039/c5tb00401b
发表时间：
2015
期刊：
J. Mater. Chem. B
影响因子：
--
作者：
Shi Chunhuan;Zhang Zhiqing;Wang Fang;Ji Xiaoqing;Zhao Zhongxi;Luan Yuxia
通讯作者：
Luan Yuxia