Frequency-dependent synaptic depression and the balance of excitation and inhibition in the neocortex
Frequency-dependent synaptic depression and the balance of excitation and inhibition in the neocortex
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DOI：
10.1038/2822
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发表时间：
1998-11-01
影响因子：
25
通讯作者：
Hestrin, S
中科院分区：
文献类型：
--
作者：
Galarreta, M;Hestrin, S
在体内皮层神经元活动的稳定性表明，兴奋性和抑制性神经元的放电率是动态调节的。使用双重记录兴奋性锥体神经元和抑制性快速尖峰神经元在新皮层切片，我们报告说，持续激活列车的几百个突触前尖峰导致更强的抑制突触电流在兴奋性突触比在抑制性的。稳态突触抑制是频率依赖性的，反映了突触前功能。这些结果表明，抑制性终端的快速尖峰细胞更好地装备，以支持长期的发射器释放在一个高的频率比兴奋的。这种频率依赖性抑制的差异可以在高整体活动期间产生相对增加的抑制影响，并促进皮层回路的稳定性。
The stability of cortical neuron activity in vivo suggests that the firing rates of both excitatory and inhibitory neurons are dynamically adjusted. Using dual recordings from excitatory pyramidal neurons and inhibitory fast-spiking neurons in neocortical slices, we report that sustained activation by trains of several hundred presynaptic spikes resulted in much stronger depression of synaptic currents at excitatory synapses than at inhibitory ones. The steady-state synaptic depression was frequency dependent and reflected presynaptic function. These results suggest that inhibitory terminals of fast-spiking cells are better equipped to support prolonged transmitter release at a high frequency compared with excitatory ones. This difference in frequency-dependent depression could produce a relative increase in the impact of inhibition during periods of high global activity and promote the stability of cortical circuits.