Seasonal variation in onset of pulmonary embolism is independent of patients' underlying risk comorbid conditions
Seasonal variation in onset of pulmonary embolism is independent of patients' underlying risk comorbid conditions
复制标题
DOI：
10.1177/107602960401000106
复制
发表时间：
2004-01-01
影响因子：
2.9
通讯作者：
Mehta, RH
中科院分区：
文献类型：
--
作者：
Manfredini, R;Gallerani, M;Mehta, RH
与许多心血管事件一样，肺栓塞（PE）并非随时间随机分布，而是呈现节律性模式。本研究的目的是调查这种时间模式的发生是否不同亚组的患者根据不同的风险共病条件。考虑了1998年至2001年在意大利费拉拉医院观察到的所有PE病例。在确定发病日期后，按性别和最常见的基础风险共病状况对人群进行分组，例如，深静脉血栓形成（DVT）、肿瘤、心肌病、创伤/外科手术、糖尿病、肺部疾病、高血压、脑血管疾病、心力衰竭、血液病。对于统计分析，使用卡方检验拟合优度和部分傅立叶级数。共纳入784例病例（平均年龄71 ± 14岁）。总人群（p = 0.002）、男性（p = 0.004）、DVT（p = 0.001）、肺部疾病（p = 0.008）、心肌病（p = 0.011）和重大创伤/外科手术（p = 0.049）的发病频率在冬季较高。时间生物学分析确定了总人口的冬季高峰（p = 0.008），男性（p
As for many cardiovascular events, pulmonary embolism (PE) is not randomly distributed over time, but shows rhythmic patterns. The purpose of this study was to investigate whether such temporal pattern of occurrence varied in subgroups of patients according to different risk comorbid conditions. All cases of PE observed at the Hospital of Ferrara, Italy, from 1998 to 2001, were considered. After determination of the day of onset, the population was grouped by gender and the most common underlying risk comorbid conditions, e.g., deep vein thrombosis (DVT), neoplasms, cardiomyopathies, traumas/surgical operations, diabetes mellitus, pulmonary diseases, hypertension, cerebrovascular diseases, heart failure, hematologic diseases. For statistical analysis, chi-square test for goodness of fit and partial Fourier series were used. A total of 784 cases (mean age 71 +/- 14 years) were included. Frequency of onset was higher in winter for total population (p=0.002), men (p=0.004), DVT (p=0.001), pulmonary disease (p=0.008), cardiomyopathies (p=0.011), and major traumas/surgical operations (p=0.049). Chronobiologic analysis identified a winter peak for total population (p=0.008), men (p