Genetic diversity and phylogenetic study of the Chinese Gelao ethnic minority via 23 Y-STR loci
Genetic diversity and phylogenetic study of the Chinese Gelao ethnic minority via 23 Y-STR loci
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中国仡佬族23个Y-STR基因座遗传多样性及系统发育研究
DOI：
10.1007/s00414-017-1743-y
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发表时间：
2018-07-01
影响因子：
2.1
通讯作者：
Hou, Yiping
中科院分区：
文献类型：
--
作者：
Chen, Pengyu;Han, Yanyan;Hou, Yiping
对贵州省道真<$佬族苗族自治县234名无血缘关系的中国仡佬族男性群体的Y染色体短串联重复序列（Y STR）23个基因座的单倍型多样性进行了分析。共检测到216种不同的单倍型，其中199种单倍型是独特的。总的单倍型多样性（HD）和辨别力（DC）分别为0.9996和0.9231。基因多样性（GD）在0.4159（DYS 438）~ 0.9650（DYS 385 a/B）之间。单倍型频率在0.0043 ~ 0.0128之间。这里提供的人口数据显示，在研究人群中具有高度的遗传多态性和非凡的辨别力。在亚洲地区的59个相邻种群中，中国仡佬族与42个种群之间存在着种群差异。多维标度分析（MDS）和系统发育树分析结果表明，在地理上相邻的湖南汉族和地理上遥远的中国藏族群体中，与中国仡佬族的遗传结构分别具有亲缘关系和分化关系。总之，我们的研究丰富了中国民族的遗传信息，可以作为法医遗传学的有力工具，用于男性检测、父系谱系分析和果敢族群体进化研究。
Haplotype diversity for 23 Y chromosomal short tandem repeat (Y-STR) loci included in the PowerPlex(A (R)) Y23 System was analyzed in the Chinese Gelao minority group of 234 unrelated males living in Daozhen Gelao-Miao Autonomous County in Guizhou Province, southwest China. A total of 216 different haplotypes were detected, of which 199 haplotypes were unique. The overall haplotype diversity (HD) and discrimination capacity (DC) were 0.9996 and 0.9231, respectively. The gene diversity (GD) ranged from 0.4159 (DYS438) to 0.9650 (DYS385a/b). The haplotype frequencies varied from 0.0043 to 0.0128. The population data presented here showed high genetic polymorphism and extraordinary discriminatory power in the studied population. Population difference was observed between the Chinese Gelao ethnicity and 42 populations out of overall 59 neighboring populations in Asia region. Both multidimensional scaling (MDS) and the phylogenetic tree demonstrated that the genetic structure affinity and differentiation with Chinese Gelao ethnicity were identified in those populations geographically adjacent (Hunan Han) and distant (Chinese Tibetan), respectively. In conclusion, our study enriched the Chinese ethnic genetic information and could be used as a powerful tool in forensic genetics for male testing, paternal lineage analysis, and Gelao ethnic population evolutionary studies.