Modeling psychiatric disorders for developing effective treatments.
Modeling psychiatric disorders for developing effective treatments.
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DOI：
10.1038/nm.3935
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发表时间：
2015-09
期刊：
影响因子：
82.9
通讯作者：
Feng G
中科院分区：
文献类型：
--
作者：
Kaiser T;Feng G
最近在识别风险基因方面取得的进展为开发用于精神疾病研究的动物模型提供了前所未有的机会，其目标是获得转化实用性以最终开发新的治疗方法。然而，在早期阶段，翻译尚未取得成功。在这里，我们回顾了精神疾病建模的最新进展，讨论了动物模型的实用性和局限性，并强调从行为分析转向识别神经生理学缺陷的重要性，这些缺陷可能在不同物种之间更为保守，从而提高了可翻译性。展望未来，我们预计临床前研究将与临床研究相结合，建立一个可比较的神经生物学异常的共同框架，并根据相似的病理生理学形成患者亚组。然后，实验神经科学可以使用动物模型来发现不同异常的机制，并制定有效的治疗策略。
The recent advance in identifying risk genes has provided an unprecedented opportunity for developing animal models for psychiatric disease research with the goal of attaining translational utility to ultimately develop novel treatments. However, at this early stage, successful translation has yet to be achieved. Here, we review recent advances in modeling psychiatric disease, discuss utility and limitations of animal models, and emphasize the importance of shifting from behavioral analysis to identifying neurophysiological defects, which are likely more conserved across species and thus increase translatability. Looking forward, we envision that preclinical research will align with clinical research to build a common framework of comparable neurobiological abnormalities and form subgroups of patients based on similar pathophysiology. Experimental neuroscience can then use animal models to discover mechanisms underlying distinct abnormalities and develop strategies for effective treatments.