An aggressive nasal lymphoma accompanied by high levels of soluble Fas ligand
An aggressive nasal lymphoma accompanied by high levels of soluble Fas ligand
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伴有高水平可溶性 Fas 配体的侵袭性鼻淋巴瘤
DOI：
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发表时间：
1996
影响因子：
6.5
通讯作者：
K. Motoyoshi
中科院分区：
文献类型：
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作者：
Kenziro Sato;F. Kimura;Yukitsugu Nakamura;Hideaki Murakami;Masayoshi Yoshida;Masato Tanaka;S. Nagata;Y. Kanatani;N. Wakimoto;N. Nagata;K. Motoyoshi
Fas 配体 (FasL)，无论是膜结合形式还是可溶形式，都对表达 Fas 的细胞具有细胞毒活性。我们报告一例伴有肝损伤和全血细胞减少的鼻淋巴瘤病例。入院时血清可溶性FasL（sFasL）水平非常高，但在淋巴瘤化疗后迅速降至正常水平。肝损伤和全血细胞减少也随着血清 sFasL 的降低而改善。由于Fas在肝细胞和造血细胞上表达，这些事实表明FasL在淋巴瘤细胞上表达，并通过其细胞毒活性与肝损伤和全血细胞减少症的发病机制直接相关。
Fas ligand (FasL), either in the membrane bound form or soluble form, has cytotoxic activity against Fas‐expressing cells. We report a case of nasal lymphoma accompanied by liver damage and pancytopenia. The serum level of soluble FasL (sFasL) was very high on admission, but rapidly decreased to normal levels after chemotherapy for lymphoma. Liver damage and pancytopenia also improved with the decrease in serum sFasL. Since Fas is expressed on both hepatocytes and haemopoietic cells, these facts suggest that FasL was expressed on lymphoma cells and directly associated with pathogenesis of liver damage and pancytopenia through its cytotoxic activity.