Nanostructured lipid matrices for improved microencapsulation of drugs
Nanostructured lipid matrices for improved microencapsulation of drugs
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DOI：
10.1016/s0378-5173(02)00180-1
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发表时间：
2002-08-21
影响因子：
5.8
通讯作者：
Wissing, SA
中科院分区：
文献类型：
--
作者：
Müller, RH;Radtke, M;Wissing, SA
在九十年代初，固体脂质纳米颗粒（SLN）作为一种由固体脂质产生的新型纳米颗粒递送系统被引入。新一代的纳米结构脂质载体（NLC）避免或最小化了与SLN相关的潜在问题，如有限的药物装载能力、药物释放谱的调整和储存过程中潜在的药物排出。NLC是由固体脂质与空间不相容的脂质混合而产生的，导致脂质基质的特殊结构，即三种类型的NLC:(I)不完全结构型，（II）无结构型和（III）多结构型。一种特殊的制备工艺-适用于NLC和sln -可以生产高浓度的颗粒分散体（> 30-95%）。描述了作为药物输送系统的潜在应用。(C) 2002 Elsevier Science B.V.版权所有
At the beginning of the nineties solid lipid nanoparticles (SLN) have been introduced as a novel nanoparticulate delivery system produced from solid lipids. Potential problems associated with SLN such as limited drug loading capacity, adjustment of drug release profile and potential drug expulsion during storage are avoided or minimised by the new generation, the nanostructured lipid carriers (NLC). NLC are produced by mixing solid lipids with spatially incompatible lipids leading to special structures of the lipid matrix, i.e. three types of NLC: (I) the imperfect structured type, (II) the structureless type and (III) the multiple type. A special preparation process-applicable to NLC but also SLN-allows the production of highly concentrated particle dispersions ( > 30-95%). Potential applications as drug delivery system are described. (C) 2002 Elsevier Science B.V. All rights reserved.