Pramipexole in comparison to l-dopa: a neuropsychological study
Pramipexole in comparison to l-dopa: a neuropsychological study
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DOI：
10.1007/s00702-002-0811-7
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发表时间：
2003-04-01
影响因子：
3.3
通讯作者：
Stanzione, P
中科院分区：
文献类型：
--
作者：
Brusa, L;Bassi, A;Stanzione, P
在一项随机研究中，使用神经心理学和临床评估对20例受早期/轻度帕金森病影响的右利手患者进行了评估，治疗方式有三种：停止治疗时、使用普拉克索时和使用1-多巴时。与停药条件相比，DA-激动剂普拉克索对短期言语记忆、注意力-执行功能和言语流畅性产生显著损害，而1-多巴则没有。此外，与1-多巴相反，普拉克索未能改善FAS和Stroop测试。目前的研究结果表明，普拉克索可能使认知功能恶化，但未超过正常值。
Twenty right-handed patients affected by early/mild Parkinson's disease were evaluated in a randomised study using neuropsychological and clinical assessements during three treatment modalities: when in the off treatment condition, when on pramipexole, and when on 1-dopa. In comparison to the off treatment condition, the DA-agonist pramipexole produced a significant impairment of short term verbal memory, attentional-executive functions and verbal fluency, while 1-dopa did not. Moreover, pramipexole opposite to 1-dopa, failed to improve FAS and Stroop tests. Present findings indicate that pramipexole may worsen cognitive functions although not exceeding normative values.