Bacillus cereus bacteremia outbreak due to contaminated hospital linens
Bacillus cereus bacteremia outbreak due to contaminated hospital linens
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DOI：
10.1007/s10096-010-1072-2
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发表时间：
2011-02-01
影响因子：
4.5
通讯作者：
Hirai, Y.
中科院分区：
文献类型：
--
作者：
Sasahara, T.;Hayashi, S.;Hirai, Y.
我们描述了2006年发生在济济医科大学医院的一起蜡状芽孢杆菌菌血症暴发。这项研究的目的是查明此次暴发的源头，并采取适当的控制措施。我们回顾了血培养蜡样芽胞杆菌阳性患者的图表，并调查了医院环境中蜡状芽胞杆菌的污染情况。对蜡样芽孢杆菌菌株间的亲缘关系进行了分析。2006年1月至8月期间，有11名患者出现蜡样芽胞杆菌菌血症。医院的床单和洗衣机受到蜡状芽孢杆菌的高度污染，这种细菌也是从静脉输液中分离出来的。所有被污染的床单都经过了高压灭菌，洗衣机用洗涤剂清洗，并在医院工作人员中宣传了手部卫生。实施这些措施后，每月出现新的蜡样芽胞杆菌菌血症的患者数量迅速减少。这次暴发的源头是医院床单上的蜡状芽胞杆菌污染，蜡状芽胞杆菌通过导管感染从床单传播给患者。我们的研究结果表明，医院床单的细菌污染会导致医院内菌血症。因此，在临床环境中，蜡样芽胞杆菌阳性的血培养不应被视为假阳性。
We describe an outbreak of Bacillus cereus bacteremia that occurred at Jichi Medical University Hospital in 2006. This study aimed to identify the source of this outbreak and to implement appropriate control measures. We reviewed the charts of patients with blood cultures positive for B. cereus, and investigated B. cereus contamination within the hospital environment. Genetic relationships among B. cereus isolates were analyzed. Eleven patients developed B. cereus bacteremia between January and August 2006. The hospital linens and the washing machine were highly contaminated with B. cereus, which was also isolated from the intravenous fluid. All of the contaminated linens were autoclaved, the washing machine was cleaned with a detergent, and hand hygiene was promoted among the hospital staff. The number of patients per month that developed new B. cereus bacteremia rapidly decreased after implementing these measures. The source of this outbreak was B. cereus contamination of hospital linens, and B. cereus was transmitted from the linens to patients via catheter infection. Our findings demonstrated that bacterial contamination of hospital linens can cause nosocomial bacteremia. Thus, blood cultures that are positive for B. cereus should not be regarded as false positives in the clinical setting.