Coupling of the Functional Stability of Rat Myocardium and Activity of Lipid Peroxidation in Combined Development of Postinfarction Remodeling and Diabetes Mellitus
Coupling of the Functional Stability of Rat Myocardium and Activity of Lipid Peroxidation in Combined Development of Postinfarction Remodeling and Diabetes Mellitus
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DOI：
10.1155/2016/2548689
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发表时间：
2016-01-01
影响因子：
4.3
通讯作者：
Popov, S. V.
中科院分区：
文献类型：
--
作者：
Afanasiev, S. A.;Kondratieva, D. S.;Popov, S. V.
已经研究了梗塞后重塑和糖尿病联合发展中大鼠心肌功能稳定性和脂质过氧化过程活性的耦合。通过分析期外收缩刺激引起的正性肌力反应、左心室肥厚程度、疤痕区大小来研究心肌功能稳定性。结果表明，在梗塞后心脏重塑（PICR）与糖尿病（DM）的联合发展中，动物体重下降的程度比糖尿病大鼠的程度要轻。具有综合病理学的动物没有心脏肥大。 PICR联合DM大鼠的期外收缩幅度与对照组相比无差异。与单独使用PICR的大鼠相比，在使用PICR联合DM的大鼠的心肌中观察到期外收缩增强。合并病理的大鼠TBA活性产物值降低。因此，研究结果表明，在梗塞后重构发展阶段诱导DM可增加心肌的适应能力。表现为抑制LPO过程活性的增加和维持与心肌细胞肌浆网钙转运系统相关的心肌力间期反应。
Coupling of the functional stability of rat myocardium and activity of lipid peroxidation processes in combined development of postinfarction remodeling and diabetes mellitus has been studied. The functional stability of myocardium was studied by means of the analysis of inotropic reaction on extrasystolic stimulus, the degree of left ventricular hypertrophy, and the size of scar zone. It was shown that in combined development of postinfarction cardiac remodeling of heart (PICR) with diabetes mellitus (DM) animal body weight decreased in less degree than in diabetic rats. Animals with combined pathology had no heart hypertrophy. Theamplitude of extrasystolic contractions in rats with PICR combined with DM had no differences compared to the control group. In myocardium of rats with PICR combined with DM postextrasystolic potentiation was observed in contrast with the rats with PICR alone. The rats with combined pathology had the decreased value of TBA-active products. Thus, the results of study showed that induction of DM on the stage of the development of postinfarction remodeling increases adaptive ability of myocardium. It is manifested in inhibition of increase of LPO processes activity and maintaining of force-interval reactions of myocardium connected with calcium transport systems of sarcoplasmic reticulum of cardiomyocytes.