Smoking and the risk of age-related macular degeneration: A meta-analysis
Smoking and the risk of age-related macular degeneration: A meta-analysis
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吸烟与年龄相关性黄斑变性的风险：一项荟萃分析
DOI：
10.1016/j.annepidem.2008.04.002
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发表时间：
2008-08-01
影响因子：
5.6
通讯作者：
Wang, Bin
中科院分区：
文献类型：
--
作者：
Cong, Rihong;Zhou, Bo;Wang, Bin
目的：一些研究评估吸烟与年龄相关性黄斑变性（AMD）之间的关系。本荟萃分析总结了吸烟和AMD的风险估计，并提供了强有力的证据association.METHODS：相关研究，确定通过检索PubMed和MEDLINE（1966年至2007年6月）和审查的关键文章的参考文献列表。计算总体相对危险比（RR）或比值比（OR）和95%置信区间（CI）。研究特定的风险估计汇总使用随机效应model.RESULTS：五个前瞻性队列研究和八个病例对照研究符合我们的纳入标准。在队列研究（RR，1.61; 95%CI，1.01-2.57）或病例对照研究（RR，1.76; 95%CI，1.56-1.99）中，既往吸烟与AMD风险增加相关，具有统计学意义。目前吸烟者比过去吸烟者患AMD的风险更高。地图状萎缩（GA）和新生血管性AMD（NV）都是AMD的亚型。吸烟和GA风险之间存在显着关系。吸烟增加了NV的风险，在队列研究中无显著性差异（RR，1.47; 95%CI，0.92-2.37），在病例对照研究中有显著性差异（RR，1.96; 95%CI，1.69-2-27）。
PURPOSE: Some studies were undertaken to evaluate the association between cigarette smoking and age-related macular degeneration (AMD). This meta-analysis summarized the risk estimate of smoking and AMD and provided robust evidence for the association.METHODS: Relevant studies were identified by searching PubMed and MEDLINE (from 1966 to June 2007) and reviewing the reference lists of key articles. The summary relative risk ratio (RR) or odds ratio (OR) and 95% confidence interval (CI) were calculated. Study-specific risk estimates were pooled using a random-effects model.RESULTS: Five prospective cohort and eight case-control studies met our inclusion criteria. Ever smoking was statistically significant associated with increased risk of AMD among cohort studies (RR, 1.61; 95% CI, 1.01-2.57) or case-control studies (RR, 1.76; 95% CI, 1.56-1.99). Current smokers were at higher risk of AMD than past smokers. Both geographic atrophy (GA) and neovascular AMD (NV) are subtypes of AMD. A significant relationship was found between smoking and GA risk. Smoking increased the risk of NV, with marginal nonsignificance (RR, 1.47; 95% CI, 0.92-2.37) in cohort studies and significance in case-control studies (RR, 1.96; 95% CI, 1.69-2-27).CONCLUSIONS: This meta-analysis indicated smoking, especially current smoking, was significantly associated with increased risks of AMD and its subtypes.