Mapping of the cerebral vascular response to hypoxia and hypercapnia using quantitative perfusion MRI at 3T
Mapping of the cerebral vascular response to hypoxia and hypercapnia using quantitative perfusion MRI at 3T
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DOI：
10.1002/nbm.1210
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发表时间：
2008-06-01
影响因子：
2.9
通讯作者：
Corfield, Douglas R.
中科院分区：
文献类型：
--
作者：
Noeth, Ulrike;Kotajima, Futoshi;Corfield, Douglas R.
呼吸的变化会改变动脉血中氧气和二氧化碳的浓度，从而导致脑血流量（CBF）的变化。这种机制可以通过脑血管反应（CVR）来描述，该反应已被证明在不同的生理和病理生理状态下发生改变。在基线条件、低氧和高碳酸血症下，采用脉冲动脉自旋标记技术在3 T下对19名受试者的灰质（GM）CBF图进行了测定。实验条件允许动脉氧（缺氧）或二氧化碳（高碳酸血症）浓度与基线相比发生变化，另一个变量保持不变，以分离这两个变量的影响。根据这些结果，计算出显示GM中CVR对缺氧和高碳酸血症的区域分布的图。CVR到缺氧的地图显示出非常高的受试者内变异，一些GM区域表现出阳性反应，而另一些区域表现出阴性反应。动脉血氧饱和度每降低10%，该组的GM-CBF就有统计学显著性增加7.0 ± 2.9%（平均SEM）。然而，70%的受试者显示总体阳性CVR（阳性应答者），其余30%的受试者显示总体阴性CVR（阴性应答者）。CVR至高碳酸血症的图显示受试者内变异较小。潮气末二氧化碳分压每增加1 mm Hg，GM-CBF就有统计学显著性增加5.8 +/- 0.9%，所有受试者均显示出总体阳性CVR。由于大脑特别容易受到缺氧的影响，这是一种与心肺疾病相关的疾病，CVR图可能有助于临床识别最容易因CVR降低而受损的区域。版权所有（C）2007约翰威利父子有限公司
Changes in breathing change the concentration of oxygen and carbon dioxide in arterial blood resulting in changes in cerebral blood flow (CBF). This mechanism can be described by the cerebral vascular response (CVR), which has been shown to be altered in different physiological and pathophysiological states. CBF maps of grey matter (GM) were determined with a pulsed arterial spin labelling technique at 3 T in a group of 19 subjects under baseline conditions, hypoxia, and hypercapnia. Experimental conditions allowed a change in either arterial oxygen (hypoxia) or carbon dioxide (hypercapnia) concentration compared with the baseline, leaving the other variable constant, in order to separate the effects of these two variables. From these results, maps were calculated showing the regional distribution of the CVR to hypoxia and hypercapnia in GM. Maps of CVR to hypoxia showed very high intra-subject variations, with some GM regions exhibiting a positive response and others a negative response. Per 10% decrease in arterial oxygen saturation, there was a statistically significant 7.0 +/- 2.9% (mean SEM) increase in GM-CBF for the group. However, 70% of subjects showed an overall positive CVR (positive responders), and the remaining 30% an overall negative CVR (negative responders). Maps of CVR to hypercapnia showed less intra-subject variation. Per 1 mm Hg increase in partial pressure of end-tidal carbon dioxide, there was a statistically significant 5.8 +/- 0.9% increase in GM-CBF, all subjects showing an overall positive CVR. As the brain is particularly vulnerable to hypoxia, a condition associated with cardiorespiratory diseases, CVR maps may help in the clinic to identify the areas most prone to damage because of a reduced CVR. Copyright (C) 2007 John Wiley & Sons, Ltd.