Preoperative plasma levels of interleukin-6 and its soluble receptor predict disease recurrence and survival of patients with bladder cancer
Preoperative plasma levels of interleukin-6 and its soluble receptor predict disease recurrence and survival of patients with bladder cancer
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DOI：
10.1016/s0022-5347(05)65348-7
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发表时间：
2002-03-01
影响因子：
6.6
通讯作者：
Lerner, SP
中科院分区：
文献类型：
--
作者：
Andrews, B;Shariat, SF;Lerner, SP
目的：白细胞介素-6（IL-6）水平升高与多种恶性肿瘤的转移和不良预后有关。由于IL-6可溶性受体（IL-6sR）增强IL-6的全身作用，因此每种都可以独立地影响疾病过程。我们测试的假设，术前血浆IL-6和IL-6sR水平将预测癌症的阶段和预后的患者与移行细胞cancerofblader.Materials和方法：研究组包括51例接受根治性膀胱移行细胞癌和44名男性无癌。结果：膀胱癌患者术前血浆IL-6水平明显高于正常对照组（P < 0.001）;在膀胱癌患者中，IL-6和IL-6sR水平升高与不良病理特征相关，包括肌肉浸润、淋巴管浸润和淋巴结转移（p < 0.05）。高水平的IL-6sR也与病理学肿瘤分级相关（p = 0.036）。在包括临床分期和分级的独立多变量模型中，IL-6和IL-6sR水平是淋巴血管浸润、淋巴结转移、疾病复发和疾病特异性生存的独立预测因子（p < 0.05）。在术前考克斯比例风险模型IL-6（p = 0.050）和IL-6sR（p = 0.035）预测疾病特异性survival.Conclusions：我们发现，血浆IL-6水平较高的膀胱癌患者比健康对照组。IL-6和IL-6sR水平与癌症分期和转移相关，并且是疾病复发和疾病特异性生存的强独立预测因子。
Purpose: Elevated levels of interleukin-6 (IL-6) are associated with metastasis and poor prognosis in various malignancies. Since the IL-6 soluble receptor (IL-6sR) potentiates the systemic effects of IL-6, each may independently impact the disease process. We tested the hypothesis that preoperative plasma IL-6 and IL-6sR levels would predict cancer stage and prognosis in patients with transitional cell carcinoma of the bladder.Materials and Methods: The study group consisted of 51 patients who underwent radical cystectomy for transitional cell carcinoma and 44 men without cancer. Preoperative plasma levels of IL-6 and IL6sR were measured by enzyme-linked immunosorbent assay and correlated with pathological features and clinical outcome.Results: IL-6 levels were higher in patients with bladder cancer than in healthy controls (p < 0.001). In bladder cancer cases elevated levels of IL-6 and IL-6sR were associated with adverse pathological features, including muscle invasion, lymphovascular invasion and lymph node metastases (p < 0.05). High levels of IL-6sR were also associated with pathological tumor grade (p = 0.036). In separate multivariate models that included clinical stage and grade IL-6 and IL-6sR levels were independent predictors of lymphovascular invasion, metastases to lymph nodes, disease recurrence and disease specific survival (p < 0.05). In a preoperative Cox proportional hazards model IL-6 (p = 0.050) and IL-6sR (p = 0.035) predicted disease specific survival.Conclusions: We found that plasma IL-6 levels were higher in patients with bladder cancer than in healthy controls. Levels of IL-6 and IL-6sR were associated with cancer stage and metastases, and were strong independent predictors of disease recurrence and disease specific survival.