Chemical Constituents of the Rhizomes of Bletilla formosana and Their Potential Anti-inflammatory Activity
Chemical Constituents of the Rhizomes of Bletilla formosana and Their Potential Anti-inflammatory Activity
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DOI：
10.1021/acs.jnatprod.6b00118
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发表时间：
2016-08-01
影响因子：
5.1
通讯作者：
Wu, Tian-Shung
中科院分区：
文献类型：
--
作者：
Lin, Che-Wei;Hwang, Tsong-Long;Wu, Tian-Shung
从白芨根茎中分离得到9个新的菲(1-9)和一个新的苄基苷(10)以及45个已知化合物。 1-10的结构主要是根据ID和2D NMR光谱数据来阐明的。评估了大多数分离化合物的抗炎活性。结果显示，抑制超氧阴离子产生和弹性蛋白酶释放的IC50值分别为0.2至6.5μM和0.3至5.7μM。还研究了分离化合物的结构活性关系。抑制效力确定为菲>联苄>联菲。
Nine new phenanthrenes (1-9) and a new benzyl glycoside (10) together with 45 known compounds were isolated from the rhizomes of Bletilla formosana. The structures of 1-10 were elucidated primarily on the basis of their ID and 2D NMR spectroscopic data. Most of the isolated compounds were evaluated for their anti-inflammatory activities. The results showed that IC50 values for the inhibition of superoxide anion generation and elastase release ranged from 0.2 to 6.5 mu M and 0.3 to 5.7 mu M, respectively. Structure activity relationships of the isolated compounds were also investigated. The inhibitory potencies were determined as phenanthrenes > bibenzyls > biphenanthrenes.