Effect of histamine receptor antagonists and indomethacin on implantation in the rabbit.
Effect of histamine receptor antagonists and indomethacin on implantation in the rabbit.
复制标题
组胺受体拮抗剂和吲哚美辛对兔植入的影响。
DOI：
10.1095/biolreprod29.4.833
复制
发表时间：
1983
影响因子：
3.6
通讯作者：
L. H. Hoffman
中科院分区：
文献类型：
--
作者：
P. Hoos;L. H. Hoffman
在第7天子宫血管通透性增加之前的24小时内，给妊娠兔服用抗炎药物。通过定量血管外伊文思蓝染料的浓度来监测抗炎药物对血管反应的影响。通常在第7天出现的血管通透性增加可被吲哚美辛或H1-(美拉明)和H2-(西咪替丁)受体拮抗剂的组合抑制。单独给药时，西咪替丁和美拉明在降低血管通透性方面都没有联合用药那么有效。前列腺素和组胺可能是共同作用的，因为同时给予较小剂量的吲哚美辛和抗组胺药物使血管通透性降低到低于单独给予任何一类抗炎药物所观察到的水平。在第二个实验中，在植入期间(第6-8天)给予抗炎药物，并在怀孕第14天评估抗炎药物对母体和胎儿组织重量以及对胎儿存活率的影响。与组胺受体拮抗剂的组合相比，吲哚美辛对这两个参数的影响更有害。这些实验的结果表明，前列腺素和组胺都可能参与子宫血管反应，而着床的整个过程似乎更依赖于前列腺素的合成，而不是组胺的作用。
Anti-inflammatory drugs were given to pregnant rabbits during the 24-h period prior to the increase in the uterine vascular permeability which occurs on Day 7. Their effect on the vascular response was monitored by quantifying the concentration of extravascular Evans blue dye. The increase in vascular permeability normally seen on Day 7 was inhibited by either indomethacin or a combination of H1-(mepyramine) and H2-(cimetidine) receptor antagonists. When given alone, neither cimetidine nor mepyramine was as effective as the combination in reducing vascular permeability. Prostaglandins and histamine may be acting together since simultaneous administration of lower doses of indomethacin and the antihistamines reduced vascular permeability below that observed following administration of either class of anti-inflammatory drugs alone. In a second experiment, anti-inflammatory drugs were administered during the peri-implantation period (Days 6-8) and their effect on the weights of maternal and fetal tissues, and on fetal viability were evaluated on Day 14 of pregnancy. Indomethacin had a more deleterious effect on both parameters than did the combination of histamine receptor antagonists. Results from these experiments suggest that both prostaglandins and histamine may participate in the uterine vascular response, whereas the overall process of implantation appears to be more dependent upon the synthesis of prostaglandins than the action of histamine.