Secondary cancer after a childhood cancer diagnosis: viewpoints considering primary cancer
Secondary cancer after a childhood cancer diagnosis: viewpoints considering primary cancer
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儿童癌症诊断后的继发性癌症：考虑原发性癌症的观点
DOI：
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发表时间：
2018
影响因子：
3.3
通讯作者：
T. Kuroda
中科院分区：
文献类型：
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作者：
Y. Ishida;M. Maeda;S. Adachi;H. Inada;H. Kawaguchi;H. Hori;A. Ogawa;K. Kudo;C. Kiyotani;H. Shichino;T. Rikiishi;R. Kobayashi;Maho Sato;J. Okamura;H. Goto;A. Manabe;S. Yoshinaga;D. Qiu;J. Fujimoto;T. Kuroda
BackgroundsMultidisciplinary治疗增加了随后的晚期效应的风险，但在儿童癌症幸存者（CCS）的继发性癌症的详细分析是有限的亚洲countries.MethodsThis是一项回顾性队列研究，包括10,069 CCSs谁被诊断为1980年和2009年之间在15家日本医院。我们进行了二次分析，根据每种原发性恶性肿瘤估计继发性癌症的发病率，并阐明原发性和继发性癌症之间的关系。我们还探讨了每个独立的原发性恶性肿瘤中继发性癌症发展的危险因素。结果原发性癌症中20年继发性癌症的累积发病率各不相同：血液系统恶性肿瘤，3.1%（95% CI 2.2-4.3）;视网膜母细胞瘤，6.6%（95% CI 1.5-16.8）;儿科实体瘤，2.5%（95% CI 1.3-4.2）;脑肿瘤，5.2%（95% CI 1.7-11.8）;骨/软组织肉瘤，5.2%（95% CI 2.3-10.1）;其他，3.3%（95% CI 1.6-6.0）（p = 0.015）。继发性癌症的累积发病率在骨肉瘤患者中最高（13.1%），其次是肝母细胞瘤（8.4%）和视网膜母细胞瘤（6.6%）。原发癌与继发癌的诊断密切相关，继发癌发生的危险因素取决于原发癌，但自体/异基因干细胞移植是一个相对常见的危险因素。原发癌与继发癌密切相关，但干细胞移植是CCS继发癌的常见危险因素。
BackgroundsMultidisciplinary therapy has increased the risk of subsequent late effects, but detailed analyses on secondary cancers in childhood cancer survivors (CCSs) are limited in Asian countries.MethodsThis was a retrospective cohort study comprising 10,069 CCSs who were diagnosed between 1980 and 2009 across 15 Japanese hospitals. We conducted secondary analyses to estimate the incidence of secondary cancer according to each primary malignancy and to elucidate the association between primary and secondary cancers. We also explored the risk factors for the development of secondary cancer in each independent primary malignancy.ResultsThe cumulative incidence of secondary cancer at 20 years varied among primary cancers: hematological malignancy, 3.1% (95% CI 2.2–4.3); retinoblastoma, 6.6% (95% CI 1.5–16.8); pediatric solid tumor, 2.5% (95% CI 1.3–4.2); brain tumors, 5.2% (95% CI 1.7–11.8) bone/soft tissue sarcoma, 5.2% (95% CI 2.3–10.1); and others, 3.3% (95% CI 1.6–6.0) (p = 0.015). The cumulative incidence of secondary cancers is highest in those with osteosarcoma (13.1%) followed by those with hepatoblastoma (8.4%) and retinoblastoma (6.6%). Close association between the primary and secondary cancer diagnoses was found. The risk factors for secondary cancer development depended on the primary cancer, but autologous/allogeneic stem cell transplantation was a relatively common risk factor.ConclusionThe cumulative incidence of secondary cancer varied among primary cancers. The primary cancer was closely associated with the secondary cancer but stem cell transplantation was a common risk factor for secondary cancers among CCSs.
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DOI：
10.1016/j.ijrobp.2011.11.022
发表时间：
2012-09-01
影响因子：
7
作者：
Henderson, Tara O.;Rajaraman, Preetha;Stovall, Marilyn;Constine, Louis S.;Olive, Aliza;Smith, Susan A.;Mertens, Ann;Meadows, Anna;Neglia, Joseph P.;Hammond, Sue;Whitton, John;Inskip, Peter D.;Robison, Leslie L.;Diller, Lisa
通讯作者：
Diller, Lisa
影响因子：
45.3
作者：
Meadows, Anna T.;Friedman, Debra L.;Inskip, Peter D.
通讯作者：
Inskip, Peter D.
影响因子：
10.3
作者：
Friedman, Debra L.;Whitton, John;Neglia, Joseph P.
通讯作者：
Neglia, Joseph P.
影响因子：
20.3
作者：
Schmiegelow, Kjeld;Al-Modhwahi, Ibrahim;Weinshilboum, Richard
通讯作者：
Weinshilboum, Richard
影响因子：
45.3
作者：
Armstrong, Gregory T.;Liu, Qi;Mertens, Ann C.
通讯作者：
Mertens, Ann C.