A conceptual model of morphogenesis and regeneration.
A conceptual model of morphogenesis and regeneration.
复制标题
DOI：
10.1007/s10441-015-9249-9
复制
发表时间：
2015-09
影响因子：
1.3
通讯作者：
Morozova N
中科院分区：
文献类型：
--
作者：
Tosenberger A;Bessonov N;Levin M;Reinberg N;Volpert V;Morozova N
本文致力于多细胞生物结构的发育和再生的计算机建模。一些物种（例如涡虫和蝾螈）能够在截肢损伤后再生部分身体，但在形态发生过程中控制细胞合作行为的总体规则尚不清楚。在这里，我们考虑一个简化的模型生物体，它由围绕特殊细胞形成的组织组成，这些细胞可以解释为干细胞。我们假设干细胞通过一组信号相互通信，并且这些信号的值取决于细胞之间的距离。因此，信号分布表征了干细胞的位置。如果信号分布发生变化，则初始信号分布和当前信号分布之间的差异会影响干细胞的行为 - 例如由于部分组织的截肢，信号分布发生变化，刺激干细胞迁移到新的位置，适合正确模式的再生。此外，当干细胞分裂并形成周围的组织时，它们控制再生组织的形式和大小。模型生物体的这种两级组织，具有干细胞的全局调节和组织的局部调节，使其可重复发育和再生。
This paper is devoted to computer modelling of the development and regeneration of multicellular biological structures. Some species (e.g., planaria and salamanders) are able to regenerate parts of their body after amputation damage, but the global rules governing cooperative cell behaviour during morphogenesis are not known. Here, we consider a simplified model organism, which consists of tissues formed around special cells that can be interpreted as stem cells. We assume that stem cells communicate with each other by a set of signals, and that the values of these signals depend on the distance between cells. Thus the signal distribution characterizes location of stem cells. If the signal distribution is changed, then the difference between the initial and the current signal distribution affects the behaviour of stem cells – e.g. as a result of an amputation of a part of tissue the signal distribution changes which stimulates stem cells to migrate to new locations, appropriate for regeneration of the proper pattern. Moreover, as stem cells divide and form tissues around them, they control the form and the size of regenerating tissues. This two-level organization of the model organism, with global regulation of stem cells and local regulation of tissues, allows its reproducible development and regeneration.