The induction of angiogenesis by cerium oxide nanoparticles through the modulation of oxygen in intracellular environments.
The induction of angiogenesis by cerium oxide nanoparticles through the modulation of oxygen in intracellular environments.
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DOI：
10.1016/j.biomaterials.2012.07.019
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发表时间：
2012-11
期刊：
影响因子：
14
通讯作者：
Seal S
中科院分区：
文献类型：
--
作者：
Das S;Singh S;Dowding JM;Oommen S;Kumar A;Sayle TX;Saraf S;Patra CR;Vlahakis NE;Sayle DC;Self WT;Seal S
血管生成是从现有血管形成新血管，并且对于许多生理和病理生理过程至关重要。在这项研究中，我们已经显示了氧化铈纳米颗粒（CNPs）诱导血管生成的独特性质，使用体外和体内模型系统观察。特别是，CNP通过调节细胞内氧环境和内源性稳定缺氧诱导因子1α来触发血管生成。此外，血管生成诱导和CNPs的物理化学性质，包括：表面Ce 3 +/Ce 4+比，表面电荷，大小和形状之间的相关性也进行了探索。高表面积和增加的Ce 3 +/Ce 4+比率使CNP对调节细胞内氧更具催化活性，这反过来导致更稳健的血管生成诱导。还使用原子模拟，与体外和体内实验合作，以揭示CNP的表面反应性和容易的氧转运促进促血管生成。
Angiogenesis is the formation of new blood vessels from existing blood vessels and is critical for many physiological and pathophysiological processes. In this study we have shown the unique property of cerium oxide nanoparticle (CNPs) to induce angiogenesis, observed using both in vitro and in vivo model systems. In particular, CNPs trigger angiogenesis by modulating the intracellular oxygen environment and stabilizing hypoxia inducing factor 1α endogenously. Furthermore, correlations between angiogenesis induction and CNPs physicochemical properties including: surface Ce3+/Ce4+ ratio, surface charge, size, and shape were also explored. High surface area and increased Ce3+/Ce4+ ratio make CNPs more catalytically active towards regulating intracellular oxygen, which in turn led to more robust induction of angiogenesis. Atomistic simulation was also used, in partnership with in vitro and in vivo experimentation, to reveal that the surface reactivity of CNPs and facile oxygen transport promotes pro-angiogenesis.