Modification of protective mechanisms against Listeria monocytogenes during pregnancy.
Modification of protective mechanisms against Listeria monocytogenes during pregnancy.
复制标题
妊娠期间针对单核细胞增生李斯特氏菌的保护机制的修改。
DOI：
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发表时间：
1981
期刊：
影响因子：
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通讯作者：
K. Takeya
中科院分区：
文献类型：
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作者：
M. Hamada;A. Kuroiwa;T. Matsumoto;K. Nomoto;K. Takeya
在C3 H/He小鼠妊娠的不同阶段，对单核细胞增生李斯特菌的保护机制进行了研究。在感染的早期阶段的细菌生长从妊娠第10天至产后第5天被抑制，而在感染的晚期阶段的细菌生长在妊娠第10天被增强。妊娠第10天未免疫小鼠的脾细胞抑制免疫小鼠对感染的获得性抗性的表达。我们的结论是，在怀孕期间在初级感染的早期阶段增强的抵抗力是由于非免疫巨噬细胞的激活，这补偿了在感染的后期阶段，可能是由于非特异性抑制细胞的功能检测到的怀孕小鼠的脾脏中的细胞介导的免疫抑制。
Protective mechanisms against Listeria monocytogenes were examined at different stages of pregnancy in C3H/He mice. Bacterial growth at an early phase of infection was depressed from day 10 of gestation to day 5 postpartum, whereas bacterial growth at a late phase of infection was enhanced on day 10 of gestation. Spleen cells from nonimmunized mice on day 10 of gestation suppressed the expression of acquired resistance to infection in immunized mice. We conclude that the augmented resistance during pregnancy at an early phase of primary infection is due to the activation of nonimmune macrophages, which compensates for the depressed cell-mediated immunity at a late phase of infection that may be due to the function of nonspecific suppressor cells detectable in the spleen of the pregnant mice.