THIAMIN STATUS OF PATIENTS TREATED WITH DRUG-COMBINATIONS CONTAINING 5-FLUOROURACIL
THIAMIN STATUS OF PATIENTS TREATED WITH DRUG-COMBINATIONS CONTAINING 5-FLUOROURACIL
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DOI：
10.1016/0014-2964(80)90251-0
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发表时间：
1980-01-01
影响因子：
8.4
通讯作者：
DICKERSON, JWT
中科院分区：
文献类型：
--
作者：
AKSOY, M;BASU, TK;DICKERSON, JWT
硫胺素的状态进行了评估，从全血转酮酶测量癌症患者在不同的网站正在与药物组合，其中包括5-氟尿嘧啶（5-FU）的治疗。9例患者的纵向测量显示，硫胺素缺乏症在5-FU治疗期间发生，并通过每天给予100 mg硫胺素进行纠正。在26例接受含5-FU方案治疗不同时间的患者中发现了类似的硫胺素缺乏症证据，但在接受不含5-FU方案治疗的患者中未发现。给予高剂量的硫胺素可降低血浆和尿中肝源性核糖核酸酶的高水平。
Thiamine status was assessed from whole blood transketolase measurements in patients with cancer in various sites being treated with drug combinations which included 5-fluorouracil (5-FU). Longitudinal measurements in 9 patients showed that thiamine deficiency developed during treatment with 5-FU and was corrected by giving 100 mg thiamine per day. Similar evidence of thiamine deficiency was found in 26 patients who were treated with 5-FU-containing regimens for varying periods of time, but was not found in patients treated with regimens not containing 5-FU. Giving high doses of thiamine reduced the high levels of plasma and urinary ribonuclease which was of hepatic origin.