Factors influencing oxygen store during denitrogenation in the healthy patient
Factors influencing oxygen store during denitrogenation in the healthy patient
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DOI：
10.1016/j.jclinane.2008.07.004
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发表时间：
2009-05-01
影响因子：
6.7
通讯作者：
Van Hal, Michael D.
中科院分区：
文献类型：
--
作者：
Ping, Sam (John) T. Sum;Makary, Laila F.;Van Hal, Michael D.
研究目的：确定影响有效预氧合率的各种因素。设计：前瞻性、随机研究。地点：教学医院的手术室。受试者：14 名 ASA 身体状况志愿者，其中 1 名志愿者以随机顺序进行 4 次呼吸。在这些志愿者中，有 7 人使用肺活量呼吸进行了两次额外的训练，这些训练也是随机完成的。干预：使用循环系统，志愿者使用吹嘴和鼻夹呼吸，直到呼出的氮气达到 5%，使用 5 L/min 或 10 L/min 的新鲜气流或用 O(2) 冲洗的系统。测量：记录呼气末的 O(2)、氮气和 CO(2) 水平。主要结果：分钟通气量、功能残气量和年龄是影响脱氮率的重要因素。然而，身高和体重并不是预测脱氮时间的重要因素。在低流速下，用 O(2) 冲洗可显着缩短脱氮时间。当使用 10 L/min O(2) 流量时，用 O(2) 冲洗似乎没有什么临床益处。结论：高气体流速对于实现快速预氧合至关重要。由爱思唯尔公司出版
Study Objective: To define the various factors that influence the rate of effective preoxygenation.Design: Prospective, randomized study.Setting: Procedure room in a teaching hospital.Subjects: 14 ASA physical status 1 volunteers who performed 4 sessions of breathing in random order. Of these volunteers, 7 performed two extra sessions using vital capacity breathing, which were also completed in random order.Interventions: Using the circle system, volunteers breathed with a mouthpiece and nose-clip until expired nitrogen reached 5%, using either a fresh gas flow of 5 L/min or 10 L/min or a system flushed with O(2).Measurements: End-expired levels of O(2), nitrogen, and CO(2) were recorded.Main Results: Minute ventilation, functional residual capacity, and age were significant factors for rate of denitrogenation. However, height and weight were not significant factors in predicting time to denitrogenation. At low flow rates, flushing with O(2) significantly decreased the time of denitrogenation. There appeared to be little clinical benefit of flushing with O(2) when a 10 L/min O(2) flow was used.Conclusions: A high gas flow rate appears critical to achieving rapid preoxygenation. Published by Elsevier Inc.