Vasodilatation of canine cerebral arteries by nicorandil, pinacidil and lemakalim.
Vasodilatation of canine cerebral arteries by nicorandil, pinacidil and lemakalim.
复制标题
尼可地尔、吡那地尔和莱马卡林对犬脑动脉的血管舒张作用。
DOI：
10.1016/0306-3623(92)90009-9
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发表时间：
1992
期刊：
影响因子：
--
通讯作者：
D. Cook
中科院分区：
文献类型：
--
作者：
H. Zhang;N. Stockbridge;B. Weir;B. Vollrath;D. Cook
1.尼可地尔、吡那地尔和lemakalim放松了犬脑动脉的预收缩环。2.效力顺序为lemakalim大于尼可地尔，约等于吡那地尔，但所有这些药物的有效性均低于尼莫地平。3.尼可地尔的作用被亚甲蓝抑制，但不被格列本脲抑制，而吡那地尔和lemakalim的作用被格列本脲抑制，但不被亚甲蓝抑制。4.因此，尼可地尔可能主要通过对鸟苷酸环化酶的作用引起舒张，而lemakalim和吡那地尔通过对ATP依赖性钾通道的作用产生相同的作用。
1. Nicorandil, pinacidil and lemakalim relaxed precontracted rings of canine cerebral artery. 2. The order of potency was lemakalim greater than nicorandil approximately equal to pinacidil, but all these agents were less effective than nimodipine. 3. The effects of nicorandil were inhibited by methylene blue but not by glibenclamide, while the effects of pinacidil and lemakalim were inhibited by glibenclamide but not by methylene blue. 4. Thus nicorandil probably causes relaxation mostly by effects on guanylate cyclase while lemakalim and pinacidil produce the same effect by action at ATP-dependent potassium channels.
来自兔主动脉的 Ca2 激活 K 通道：cromakalim 的调节。
影响因子：
5
作者：
Gelband,CH;Lodge,NJ;VanBreemen,C
通讯作者：
VanBreemen,C
影响因子：
56.9
作者：
STANDEN, NB;QUAYLE, JM;NELSON, MT
通讯作者：
NELSON, MT