A COMMUNITY TRIAL OF THE IMPACT OF IMPROVED SEXUALLY-TRANSMITTED DISEASE TREATMENT ON THE HIV EPIDEMIC IN RURAL TANZANIA .2. BASE-LINE SURVEY RESULTS
A COMMUNITY TRIAL OF THE IMPACT OF IMPROVED SEXUALLY-TRANSMITTED DISEASE TREATMENT ON THE HIV EPIDEMIC IN RURAL TANZANIA .2. BASE-LINE SURVEY RESULTS
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DOI：
10.1097/00002030-199508000-00015
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发表时间：
1995-08-01
期刊：
影响因子：
3.8
通讯作者：
HAYES, R
中科院分区：
文献类型：
--
作者：
GROSSKURTH, H;MOSHA, F;HAYES, R
目标：在一项改进性传播疾病 (STD) 治疗试验中确定艾滋病毒患病率的基线，并调查艾滋病毒的危险因素。评估干预和比较社区在艾滋病毒/性病流行率和风险因素方面的可比性。评估样本量的充分性。设置：坦桑尼亚姆万扎地区的 12 个社区：一对匹配的路边社区、四对农村社区和一对岛屿社区。基线调查后，每对中随机分配一个社区接受性病干预。方法：从每个社区随机抽取约 1000 名 15-54 岁成年人。对受试者进行访谈，并进行艾滋病毒和梅毒血清学检查。尿液白细胞酯酶试纸测试呈阳性或报告当前患有 STD 的男性接受了尿道感染检测。 结果：总共招募了 12 534 名成年人。艾滋病毒基线感染率分别为 7.7%（路边）、3.8%（农村）和 1.8%（岛屿）。观察了婚姻状况、注射、教育、旅行、性病史和梅毒血清学之间的关联。接受包皮环切的男性的患病率较高，但在调整混杂因素后差异不显着。干预社区和比较社区在艾滋病毒（3.8% 对 4.4%）、活动性梅毒（8.7% 对 8.2%）和大多数记录的危险因素的患病率方面相似。 HIV 患病率的配对内变异性接近样本量计算的假设值。结论：试验队列成功建立。大多数因素都证实了干预社区和比较社区在基线时的可比性。匹配似乎已经实现了足够样本量的试验。与非洲的其他研究相比，男性包皮环切明显缺乏保护作用。
Objectives: To determine baseline HIV prevalence in a trial of improved sexually transmitted disease (STD) treatment, and to investigate risk factors for HIV. To assess comparability of intervention and comparison communities with respect to HIV/STD prevalence and risk factors. To assess adequacy of sample size.Setting: Twelve communities in Mwanza Region, Tanzania: one matched pair of roadside communities, four pairs of rural communities, and one pair of island communities. One community from each pair was randomly allocated to receive the STD intervention following the baseline survey.Methods: Approximately 1000 adults aged 15-54 years were randomly sampled from each community. Subjects were interviewed, and HIV and syphilis serology performed. Men with a positive leucocyte esterase dipstick test on urine, or reporting a current STD, were tested for urethral infections.Results: A total of 12 534 adults were enrolled. Baseline HIV prevalences were 7.7% (roadside), 3.8% (rural) and 1.8% (islands). Associations were observed with marital status, injections, education, travel, history of STD and syphilis serology. Prevalence was higher in circumcized men, but not significantly after adjusting for confounders. Intervention and comparison communities were similar in the prevalence of HIV (3.8 versus 4.4%), active syphilis (8.7 versus 8.2%), and most recorded risk factors. Within-pair variability in HIV prevalence was close to the value assumed for sample size calculations.Conclusions: The trial cohort was successfully established. Comparability of intervention and comparison communities at baseline was confirmed for most factors. Matching appears to have achieved a trial of adequate sample size. The appartent lack of a protective effect of male circumcision contrasts with other studies in Africa.