TENSILE PROPERTIES OF HUMAN KNEE-JOINT CARTILAGE .1. INFLUENCE OF IONIC CONDITIONS, WEIGHT BEARING, AND FIBRILLATION ON THE TENSILE MODULUS
TENSILE PROPERTIES OF HUMAN KNEE-JOINT CARTILAGE .1. INFLUENCE OF IONIC CONDITIONS, WEIGHT BEARING, AND FIBRILLATION ON THE TENSILE MODULUS
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DOI：
10.1002/jor.1100040401
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发表时间：
1986-01-01
影响因子：
2.8
通讯作者：
MANICOURT, DH
中科院分区：
文献类型：
--
作者：
AKIZUKI, S;MOW, VC;MANICOURT, DH
已经测量了正常、原纤化和骨关节炎（从全膝关节置换物中去除）软骨的人膝关节软骨的细胞外基质的流动非依赖性（固有）拉伸模量。在我们的等轴拉伸仪中测定模量，并在平衡状态下测量。我们发现线性平衡应力-应变行为高达. apprx。15%应变测量了关节表面高和低负重区、内侧股骨髁和外侧髌股沟以及组织内不同区域（表面、表面下、中间和中深）组织的模量。对于所有试样，固有拉伸模量始终小于30 MPa。来自低负重区（LWA）的组织比来自高负重区（HWA）的组织更硬。ECM的拉伸模量与胶原蛋白/蛋白聚糖比率密切相关; LWA的拉伸模量高于HWA。来自全膝关节置换手术的骨关节炎软骨具有小于2 MPa的拉伸刚度。
The flow-independent (intrinsic) tensile modulus of the extracellular matrix of human knee joint cartilage has been measured for normal, fibrillated, and osteoarthritic (removed from total knee joint replacements) cartilage. The modulus was determined in our isometric tensile apparatus and measured at equilibrium. We found a linear equilibrium stress-strain behavior up to .apprx. 15% strain. The modulus was measured for tissues from the high and low weight-brearing areas of the joint surfaces, the medial femoral condyle and lateral patello femoral groove, and from different zones (surface, subsurface, middle, and middle-deep) within the tissue. For all specimens, the intrinsic tensile modulus was always less than 30 MPa. Tissues from low weight-bearing areas (LWA) are stiffer than those from high weight-bearing areas (HWA). The tensile modulus of the ECM correlates strongly with the collagen/proteoglycan ratio; it is higher for LWA than for HWA. Osteoarthritic cartilage from total knee replacement procedures has a tensile stiffness less than 2 MPa.