Helicobacter pylori induces urease subunit B‐specific CD8+ T cell responses in infected individuals via cytosolic pathway of cross‐presentation
Helicobacter pylori induces urease subunit B‐specific CD8+ T cell responses in infected individuals via cytosolic pathway of cross‐presentation
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DOI：
10.1111/hel.13005
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发表时间：
2023-06
期刊：
影响因子：
4.4
通讯作者：
Zelin Zhang;Xingchi Chen;Bin Li;T. Xia;Xiaobin Wu;Chao Wu
中科院分区：
文献类型：
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作者：
Zelin Zhang;Xingchi Chen;Bin Li;T. Xia;Xiaobin Wu;Chao Wu
尿素酶亚单位B（UreB）是幽门螺杆菌（Helicobacter pylori，H. pylori），可以诱导宿主CD4+ T细胞免疫应答以提供保护，但关于CD8+ T细胞应答知之甚少。研究了H.幽门螺杆菌特异性CD8+ T细胞应答和抗原加工和呈递途径的机制仍不清楚。本研究以保护性抗原重组UreB（rUreb）为靶点，在体外检测特异性CD8+ T细胞反应，探讨UreB抗原加工和呈递的机制。
Urease subunit B (UreB), a conserved and key virulence factor of Helicobacter pylori (H. pylori), can induce the host CD4+ T cell immune responses to provide protection, but less is known regarding CD8+ T cell responses. The characteristics of H. pylori‐specific CD8+ T cell responses and the mechanism underlying antigen processing and presentation pathways remain unclear. This study was focus on protective antigen recombinant UreB (rUreb) to detect specific CD8+ T cell responses in vitro and elucidate the mechanism of UreB antigen processing and presentation.