Presynaptic D1 dopamine receptors facilitate glutamatergic neurotransmission in the rat globus pallidus
Presynaptic D1 dopamine receptors facilitate glutamatergic neurotransmission in the rat globus pallidus
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DOI：
10.1016/j.neulet.2007.08.026
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发表时间：
2007-10-02
影响因子：
2.5
通讯作者：
Aceves, Jorge
中科院分区：
文献类型：
--
作者：
Hernandez, Adan;Sierra, Arturo;Aceves, Jorge
在TTX和荷包牡丹碱存在下，采用全细胞记录法研究了D1/5多巴胺受体激动剂对大鼠苍白球神经元自发兴奋性突触后电流（sEPSC）的影响。在这种情况下，CNQX消除了sEPSC，表明它们仅由AMPA受体介导。SKF 38393是一种D1样激动剂，增加了sEPSC的频率，但没有增加振幅，表明作用于突触前位点。频率的增加被D1/5拮抗剂SCH 23390阻断。类D2激动剂Quinpirole可降低突触电流的频率，但不影响突触电流的振幅。SKF 38393增加了sEPSC电流的频率，即使在存在喹吡罗的情况下也是如此，这表明D1/5和D2样受体独立地调节单个神经元上的谷氨酸释放。结果表明，苍白球中多巴胺能对谷氨酸传递的控制可能在基底神经节间接途径中处理皮质信息中发挥作用。(C)2007爱思唯尔爱尔兰有限公司保留所有权利。
The effects of D1/5 dopamine agonists on spontaneous excitatory postsynaptic currents (sEPSCs) were studied in neurons of the rat globus pallidus using whole-cell recordings in the presence of TTX and bicuculline. In this condition, CNQX abolished the sEPSCs, indicating that they were solely mediated by AMPA receptors. SKF 38393, a D1-like agonist, increased the frequency but not the amplitude of the sEPSCs, suggesting a presynaptic site of action. The increase in frequency was blocked by SCH 23390, a D1/5 antagonist. Quinpirole, a D2-like agonist, decreased the frequency but did not affect the amplitude of the synaptic currents. SKF 38393 increased the frequency of sEPSCs currents, even in presence of quinpirole, indicating that D 1/5- and D2-like receptors independently modulate glutamate release upon a single neuron. The results suggest that the dopaminergic control of the glutamate transmission in the globus pallidus may play a role in processing cortical information in the indirect pathway of the basal ganglia. (C) 2007 Elsevier Ireland Ltd. All rights reserved.