FORMATION OF PROSTAGLANDINS BY OVARIAN CARCINOMAS
FORMATION OF PROSTAGLANDINS BY OVARIAN CARCINOMAS
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DOI：
10.1016/0090-6980(85)90128-5
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发表时间：
1985-01-01
影响因子：
2.9
通讯作者：
ZAHRADNIK, HP
中科院分区：
文献类型：
--
作者：
BAUKNECHT, T;SIEGEL, A;ZAHRADNIK, HP
本文测定了11例晚期卵巢癌组织中前列腺素E_2、PGE_2 α和前列腺素E_2降解产物6-酮-前列腺素F_1 α（6-keto-PGF_（1a））的含量。PG水平（ng/mg组织蛋白）变化很大：PGE 2 17 - 515; PGF 2a 2 - 43和6-keto-PGF 1a 5 - 105。对化疗[顺铂、环磷酰胺和阿霉素]无反应的患者的肿瘤比对化疗有反应的肿瘤含有更多的PGE2、PGF2a和6-keto-PGF1a。PG生产进行了研究，在2卵巢癌衍生的细胞系。这些细胞合成PG的能力根据细胞密度而变化。细胞数量的增加与PG产量的下降有关。PG的形成被吲哚美辛以浓度依赖的方式抑制。显然，卵巢癌细胞在体内和体外形成PG。
Tissue contents of prostaglanidns (PG) PGE2, PGE2a and 6-keto-PGF1a (degradation product of PGI2) were determined in specimens of advanced human ovarian cancer (n = 11). The PG levels (ng/mg tissue protein) varied widely: PGE2 17-515; PGF2a 2-43 and 6-keto-PGF1a 5-105. Tumors of patients without response to chemotherapy [cisplatinum, cyclophosphamide and adriamycin] contained more PGE2, PGF2a and 6-keto-PGF1a than did tumors responding to chemotherapy. PG production was investigated in 2 ovarian carcinoma-derived cell lines. The ability of these cells to synthesize PG varied depending on the cell density. An increase of cell number was associated with decrease of PG yield. PG formation was inhibited by indomethacin in a concentration-dependent manner. Apparently, ovarian carcinoma cells form PG in vivo and vitro.