Dentin matrix proteins and dentinogenesis.
Dentin matrix proteins and dentinogenesis.
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DOI：
10.3109/03008209509016983
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发表时间：
1995-01-01
影响因子：
2.9
通讯作者：
Butler, W T
中科院分区：
文献类型：
--
作者：
Butler, W T
牙本质形成的确切机制尚不清楚，然而，迄今为止的信息表明，涉及许多高度受控的细胞外事件。成熟的成牙本质细胞在细胞边缘分泌胶原进入前牙本质。它们可能通过成牙本质细胞过程在矿化前沿合成和分泌其他非胶原蛋白（NCP）。在前牙本质-牙本质边界处形成胶原-NCP复合物，并且发生磷灰石晶体的起始和生长。研究需要之一是揭示这种牙本质胶原-NCP复合物的性质，并了解它如何控制矿化。已知至少有三种牙本质特异性NCP：磷酸化蛋白（phosphophoryn）、牙本质唾液蛋白（DSP）和AG 1（Dmp 1）。其他大分子通常由成骨细胞和成牙本质细胞产生，并参与骨和牙本质的形成。通过研究磷素在牙本质矿化中的作用，人们对牙本质矿化的认识取得了一些进展。这些高度磷酸化的蛋白质在矿化前沿分泌，其中一小部分结合在I型胶原原纤维的差距区域。磷蛋白的这一部分可能引发板状磷灰石晶体的形成。较高浓度的磷炔与生长中的磷灰石晶体结合，减缓其生长，可能影响其大小和形状。其他需要仔细研究的领域是那些涉及成牙本质细胞分化的机制，如何控制牙本质特异性NCP的合成以及这些大分子在牙本质形成中的确切作用。未来的实验将集中在这些NCP的基因结构和组织特异性基因调控的机制。（250字处删节）
The precise mechanisms involved in dentinogenesis are not understood; however, the information to date suggests that a number of highly controlled extracellular events are involved. Mature odontoblasts secrete collagen at the cell border into predentin. They synthesize and secrete other non-collagenous proteins (NCPs) at the mineralization front, possibly through odontoblastic processes. A collagen-NCP complex is formed at the predentin-dentin border and apatite crystal initiation and growth takes place. One of the research needs is to uncover the nature of this dentin collagen-NCP complex and to understand how it controls mineralization. At least three dentin specific NCPs are known: phosphophoryn(s), dentin sialoprotein (DSP) and AG1 (Dmp1). Other macromolecules are commonly made by osteoblasts and odontoblasts and participate in bone and dentin formation. Some progress in understanding dentin mineralization has been gained by focusing upon the role of phosphophoryns. These highly phosphorylated proteins are secreted at the mineralization front, where a small portion binds in the gap region of type I collagen fibrils. This portion of phosphoproteins probably initiates formation of plate-like apatite crystals. Additional phosphoryns in higher concentrations bind to the growing apatite crystals and slow their growth, possibly influencing their size and shape. Other areas which need careful investigations are those involving the mechanisms involved in odontoblast differentiation, how the synthesis of the dentin specific NCPs is controlled and the precise roles of these macromolecules in dentinogenesis. Future experimentation will focus on the gene structures for these NCPs and the mechanisms of tissue specific gene regulation.(ABSTRACT TRUNCATED AT 250 WORDS)