Glucosamine induces autophagy via an mTOR-independent pathway
Glucosamine induces autophagy via an mTOR-independent pathway
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DOI：
10.1016/j.bbrc.2009.12.154
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发表时间：
2010-01-22
影响因子：
3.1
通讯作者：
Ashida, Hisashi
中科院分区：
文献类型：
--
作者：
Shintani, Tomoya;Yamazaki, Fumiyoshi;Ashida, Hisashi
自噬是一种非特异性降解细胞质成分的细胞过程，参与许多细胞反应。我们发现含有游离氨基的氨基糖，如葡萄糖胺、半乳糖胺和甘露糖胺，通过不依赖于rntor的途径诱导自噬。在浓度至少为500 μ M至超过40 mM的情况下，氨基葡萄糖诱导的自噬在6 h开始诱导，在36 h达到平台期。氨基葡萄糖诱导的自噬可以去除积累的泛素结合蛋白和79-谷氨酰胺重复序列。因此，口服葡萄糖胺可能有助于预防神经退行性疾病和促进抗衰老作用。(C) 2010爱思唯尔公司版权所有。
Autophagy is a cellular process that nonspecifically degrades cytosolic components and is involved in many cellular responses. We found that amino sugars with a free amino group such as glucosamine, galactosamine and mannosamine induced autophagy via an rnTOR-independent pathway. Glucosamine-induced autophagy at concentrations of at least 500 mu M to over 40 mM. In the presence of 40 mM glucosamine, autophagy induction was initiated at 6 h and reached a plateau at 36 h. Glucosamine-induced autophagy could remove accumulated ubiquitin-conjugated proteins as well as 79-glutamine repeats. Therefore, Orally administered glucosamine could contribute to the prevention of neurodegenerative diseases and promotion of antiaging effects. (C) 2010 Elsevier Inc. All rights reserved.