Transcranial direct current stimulation for depression: 3-week, randomised, sham-controlled trial
Transcranial direct current stimulation for depression: 3-week, randomised, sham-controlled trial
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DOI：
10.1192/bjp.bp.111.097634
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发表时间：
2012-01-01
影响因子：
10.5
通讯作者：
Sachdev, Perminder
中科院分区：
文献类型：
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作者：
Loo, Colleen K.;Alonzo, Angelo;Sachdev, Perminder
研究背景经颅直流电刺激（transcranial direct current stimulation，tDCS）具有抗抑郁作用，目的通过一项双盲、假对照试验（www.example.com：NCT 00763230）进一步研究tDCS的疗效www.clinicaltrials.gov（2mA，3周内15次），然后是3周的开放标签活性治疗期。结果主动治疗组的情绪改善程度明显高于假治疗组（P
BackgroundPreliminary evidence suggests transcranial direct current stimulation (tDCS) has antidepressant efficacy.AimsTo further investigate the efficacy of tDCS in a double-blind, sham-controlled trial (registered at www.clinicaltrials.gov: NCT00763230).MethodSixty-four participants with current depression received active or sham anodal tDCS to the left prefrontal cortex (2mA, 15 sessions over 3 weeks), followed by a 3-week open-label active treatment phase. Mood and neuropsychological effects were assessed.ResultsThere was significantly greater improvement in mood after active than after sham treatment (P