The correlation between phase shifts in gradient-echo MR images and regional brain iron concentration
The correlation between phase shifts in gradient-echo MR images and regional brain iron concentration
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DOI：
10.1016/s0730-725x(99)00017-x
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发表时间：
1999-10-01
影响因子：
2.5
通讯作者：
Taylor, JS
中科院分区：
文献类型：
--
作者：
Ogg, RJ;Langston, JW;Taylor, JS
本研究旨在探讨脑组织磁化率与铁浓度的关系。对21名年龄在0.7-45岁的受试者进行了梯度回波图像(TE=60ms)的相移测量，并与已发表的局部脑铁浓度进行了比较。在壳核(R2=0.76)、尾状核(0.72)、运动皮质(0.68)、苍白球(0.59)和额叶皮质(R2=0.19，P=0.0 5)，时相与脑铁浓度呈正相关(R2=0.19，P=0.0 5)，但与脑白质无关(R2=0.0 5，P 0.34)。回归斜率(度/毫克铁/克组织湿重)在很小的范围内变化，从苍白球和额叶皮质的-1.2到尾状核的-2.1，这些结果表明磁共振时相反映了铁诱导的脑组织灰质敏感性的差异。白质缺乏相关性可能反映了灰质和白质在细胞分布和铁的代谢功能方面的重要差异。磁共振相位图像提供了对脑组织磁状态的洞察，并可能被证明有助于阐明脑铁和组织松弛特性之间的关系。(C)1999年爱思唯尔科学公司。
The purpose of this study was to investigate the relationship between the magnetic susceptibility of brain tissue and iron concentration. Phase shifts in gradient-echo images (TE = 60 ms) were measured in 21 human subjects, (age 0.7-45 years) and compared with published values of regional brain iron concentration. Phase was correlated with brain iron concentration in putamen (R-2 = 0.76), caudate (0.72), motor cortex (0.68), globus pallidus (0.59) (all p < 0.001), and frontal cortex (R-2 = 0.19, p = 0.05), but not in white matter (R-2 = 0.05,p 0.34). The slope of the regression (degrees/mg iron/g tissue wet weight) varied over a narrow range from -1.2 in the globus pallidus and frontal cortex to -2.1 in the caudate, These results suggest that magnetic resonance phase reflects iron-induced differences in brain tissue susceptibility in gray matter. The lack of correlation in white matter may reflect important differences between gray and white matter in the cellular distribution and the metabolic functions of iron. Magnetic resonance phase images provide insight into the magnetic state of brain tissue and may prove to be useful in elucidating the relationship between brain iron and tissue relaxation properties. (C) 1999 Elsevier Science Inc.