Advanced Glycation End Products in Patients with Cerebral Infarction
Advanced Glycation End Products in Patients with Cerebral Infarction
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DOI：
10.2169/internalmedicine.48.1390
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发表时间：
2009-01-01
影响因子：
1.2
通讯作者：
Miyata, Toshio
中科院分区：
文献类型：
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作者：
Ohnuki, Yuko;Nagano, Reiko;Miyata, Toshio
目的碳水化合物和脂质的氧化修饰促进了晚期糖基化终产物（AGEs）的形成，这种产物不仅在高血糖状态下形成，在正常血糖状态下也会形成。在这项研究中，我们测定了脑梗死患者的皮肤AGEs。患者和方法我们使用AGE Reader无创测量了慢性脑梗死（CCI, n=95）、无症状脑梗死（SBI, n=40）和年龄匹配对照组（n=34）的皮肤自身荧光（AF）水平。结果与对照组相比，CCI和SBI患者皮肤AF水平显著升高（分别为2.06+/-0.38、2.16+/-0.47和1.84+/-0.35）。血管紧张受体阻滞剂（ARB）或他汀类药物对任何组的晚期糖基化水平均无显著影响。结论AGEs的形成增加可能是氧化应激的一个指标，不仅在糖尿病和肾功能衰竭中如此，在慢性脑缺血中也是如此。
Objective Oxidative modification of carbohydrates and lipids enhances the formation of advanced glycation end products (AGEs), which are formed not only in hyperglycemia, but also in normoglycemia. In this study, we determined skin AGEs in patients with cerebral infarction.Patients and Methods We non-invasively measured skin autofluorescence (AF) levels in patients with chronic cerebral infarction (CCI; n=95), patients with silent brain infarction (SBI; n=40), and age-matched controls (n=34), using an AGE Reader.Results Skin AF levels in patients with CCI and SBI were significantly increased compared with those in the control group (2.06+/-0.38, 2.16+/-0.47 and 1.84+/-0.35, respectively). Angiotension receptor blocker (ARB) or statins had no significant effect on the level of advanced glycation in any of the groups.Conclusion Our data suggest that increased formation of AGEs may be an indicator of oxidative stress, not only in diabetes and renal failure, but also in chronic cerebral ischemia.