Coronary artery disease is associated with Alzheimer disease neuropathology in APOE4 carriers
Coronary artery disease is associated with Alzheimer disease neuropathology in APOE4 carriers
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DOI：
10.1212/01.wnl.0000210447.19748.0b
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发表时间：
2006-05-09
期刊：
影响因子：
9.9
通讯作者：
Haroutunian, V
中科院分区：
文献类型：
--
作者：
Beeri, MS;Rapp, M;Haroutunian, V
目的：探讨死后阿尔茨海默病（AD）神经病理与尸检证实的心血管疾病之间的关系。研究方法：作者检查了来自西奈山医学院精神病学系脑库的99名受试者（死亡时平均年龄= 87.6; SD = 8.7），他们没有脑血管疾病相关病变或非AD相关神经病理学。测量神经炎斑块（NPs）和神经纤维缠结（NFT）的密度以及冠状动脉和主动脉粥样硬化、左心室壁厚度和心脏重量。在控制死亡年龄、性别、痴呆严重程度、体重指数和ApoE基因型后，使用偏相关性评估4个心血管变量与海马、内嗅皮层和大脑皮层多个区域的NP和NFT的相关性。还对ApoE 4携带者和非携带者分别重复了这些分析。结果如下：在该尸检样本中，冠状动脉疾病的程度和较小程度的动脉粥样硬化与AD的主要神经病理学病变的密度显著相关（0.22和0.29之间的显著相关性）。这些相关性在ApoE 4等位基因携带者中更为明显（n = 42;显著相关性在0.34和0.47之间）。结论：冠状动脉病变程度与Alzheimer病主要神经病变独立相关。这些关联主要归因于具有ApoE 4等位基因的个体。
Objective: To examine the associations between postmortem Alzheimer disease (AD) neuropathology and autopsy-verified cardiovascular disease. Methods: The authors examined 99 subjects (mean age at death = 87.6; SD = 8.7) from the Mount Sinai School of Medicine Department of Psychiatry Brain Bank who were devoid of cerebrovascular disease-associated lesions or of non-AD-related neuropathology. Density of neuritic plaques (NPs) and neurofibrillary tangles (NFTs) as well as coronary artery and aortic atherosclerosis, left ventricular wall thickness, and heart weight were measured. Partial correlations were used to assess the associations of the four cardiovascular variables with NPs and NFTs in the hippocampus, entorhinal cortex, and multiple regions of the cerebral cortex after controlling for age at death, sex, dementia severity, body mass index, and ApoE genotype. These analyses were also repeated separately for ApoE4 carriers and noncarriers. Results: The extent of coronary artery disease and to a lesser extent atherosclerosis were significantly associated with the density of cardinal neuropathologic lesions of AD in this autopsy sample (significant correlations between 0.22 and 0.29). These associations were more pronounced for the ApoE4 allele carriers (n = 42; significant correlations between 0.34 and 0.47). Conclusions: The degree of coronary artery disease is independently associated with the cardinal neuropathological lesions of Alzheimer disease. These associations are primarily attributable to individuals with the ApoE4 allele.