Elevation of dopamine levels in parasitized insect larvae
Elevation of dopamine levels in parasitized insect larvae
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寄生昆虫幼虫中多巴胺水平升高
DOI：
10.1016/0965-1748(94)00054-l
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发表时间：
1995
影响因子：
3.8
通讯作者：
R. Downer
中科院分区：
文献类型：
--
作者：
H. Noguchi;Y. Hayakawa;R. Downer
粘虫的末龄幼虫，粘虫，Pseudaletia separata，寄生在寄生蜂，Cotesia kariyai，遭受生长迟缓，不开始变态。寄生蜂能提高寄主末龄幼虫血淋巴和神经索中多巴胺的含量。多巴胺水平的升高是通过注射多脱氧核糖核酸病毒或生长阻断肽（GBP）来复制的。注射多巴胺或多巴胺激动剂（-）-喹吡罗，干扰粘虫幼虫的正常发育。这些结果表明，多DNA病毒感染引起的GBP升高引起血淋巴和神经系统中多巴胺的增加，这与正常幼虫发育障碍密切相关。
Last instar larvae of the armyworm, Pseudaletia separata, parasitized with the parasitoid wasp, Cotesia kariyai, suffer from retarded growth and do not initiate metamorphosis. Dopamine levels in hemolymph and nerve cord of host last instar larvae were increased by parasitization with parasitoid wasps. The elevation of dopamine levels was reproduced by injection with polydnavirus or growth-blocking peptide (GBP). Injection of dopamine or the dopamine agonist, (-)-Quinpirole, disturbs normal development of the armyworm larvae. These results suggest that GBP elevated by polydnavirus infection causes an increase of dopamine in hemolymph and nervous system, which is closely related to a disturbance of normal larval development.