Metabolic regulation of stem cell function.
Metabolic regulation of stem cell function.
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DOI：
10.1111/joim.12247
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发表时间：
2014-07
影响因子：
11.1
通讯作者：
Morrison SJ
中科院分区：
文献类型：
--
作者：
Burgess RJ;Agathocleous M;Morrison SJ
干细胞功能受内在机制（如转录和表观遗传调节因子）以及外在机制（如来自小生境的短程信号和长程体液信号）调节。这些调节机制和细胞代谢之间的相互作用刚刚开始被确定。在多个系统中，分化伴随着糖酵解、氧化磷酸化和活性氧水平的变化。事实上，代谢途径通过调节能量产生和生物合成途径底物的产生来调节增殖和分化。与限制性祖细胞和分化细胞相比，干细胞中的一些代谢途径似乎功能不同。它们似乎还通过调节信号转导、表观遗传标记和氧化应激来影响干细胞功能。迄今为止的研究表明代谢在干细胞功能调节中的重要性，并表明代谢和其他干细胞调节机制之间可能存在复杂的交叉调节。
Stem cell function is regulated by intrinsic mechanisms, such as transcriptional and epigenetic regulators, as well as extrinsic mechanisms, such as short-range signals from the niche and long-range humoral signals. Interactions between these regulatory mechanisms and cellular metabolism are just beginning to be identified. In multiple systems, differentiation is accompanied by changes in glycolysis, oxidative phosphorylation, and the levels of reactive oxygen species. Indeed, metabolic pathways regulate proliferation and differentiation by regulating energy production and the generation of substrates for biosynthetic pathways. Some metabolic pathways appear to function differently in stem cells as compared with restricted progenitors and differentiated cells. They also appear to influence stem cell function by regulating signal transduction, epigenetic marks, and oxidative stress. Studies to date illustrate the importance of metabolism in the regulation of stem cell function and suggest complex cross regulation likely exists between metabolism and other stem cell regulatory mechanisms.
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影响因子：
56.9
作者：
Choudhary, Chunaram;Kumar, Chanchal;Mann, Matthias
通讯作者：
Mann, Matthias
影响因子：
5.9
作者：
Comes, Stefania;Gagliardi, Miriam;Laprano, Nicola;Fico, Annalisa;Cimmino, Amelia;Palamidessi, Andrea;De Cesare, Dario;De Falco, Sandro;Angelini, Claudia;Scita, Giorgio;Patriarca, Eduardo J.;Matarazzo, Maria R.;Minchiotti, Gabriella
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影响因子：
8.8
作者：
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通讯作者：
Chen D
影响因子：
14.8
作者：
Bracha, Abigail L.;Ramanathan, Arvind;Huang, Sui;Ingber, Donald E.;Schreiber, Stuart L.
通讯作者：
Schreiber, Stuart L.
DOI：
10.1073/pnas.1111312108
发表时间：
2011-09-20
影响因子：
11.1
作者：
Alexander, Peter B.;Wang, Jian;McKnight, Steven L.
通讯作者：
McKnight, Steven L.