Quantification of opioid receptor availability following spontaneous epileptic seizures: correction of [11C]diprenorphine PET data for the partial-volume effect
Quantification of opioid receptor availability following spontaneous epileptic seizures: correction of [11C]diprenorphine PET data for the partial-volume effect
复制标题
自发性癫痫发作后阿片受体可用性的量化：校正[11C]二丙诺啡 PET 数据的部分容量效应
DOI：
10.1016/j.neuroimage.2013.04.015
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发表时间：
2013
期刊：
影响因子：
5.7
通讯作者：
Koepp MJ.
中科院分区：
文献类型：
--
作者：
McGinnity CJ;Shidahara M;Feldmann M;Keihaninejad S;Riano Barros DA;Gousias IS;Duncan JS;Brooks DJ;Heckemann RA;Turkheimer FE;Hammers A;Koepp MJ.
既往使用非选择性阿片受体拮抗剂[11 C]二丙诺啡（DPN）对难治性颞叶癫痫（TLE）进行的正电子发射断层扫描（PET）研究未检测到内侧颞叶结构的任何变化，尽管已知海马参与癫痫发作。在较小的海马中的正常结合暗示了在剩余的灰质中受体浓度的增加。部分容积效应（PVE）校正尚未在既往DPN PET研究中使用。在这里，我们提出了PVE校正的DPN-PET数据定量发作后和发作间期阿片受体的可用性在人类与mTLE。发作后和发作间期DPN PET扫描的八个配对数据集和十一个测试/再测试对照数据集可从先前发表的关于癫痫发作后TLE中阿片受体变化的研究中获得（Hammers等人，2007年a）。八名TLE参与者中有五名记录了海马硬化。使用感兴趣的区域和新的PVE校正方法（结构功能协同分辨率恢复（SFS-RR）;（Shidahara等人，2012年））。对数据进行去噪，然后应用SFS-RR，其中解剖信息经由参与者的MRI的精确解剖分割（MAPER;（Heckemann等人，2010年））。[11 C]二丙诺啡分布容积（VT）在六个感兴趣的区域进行定量。在同侧梭状回和外侧颞极观察到发作后增加。一个新的发现是发作后[11 C]DPN VT相对于同侧海马旁回发作间期状态增加，未在未校正的数据集中观察到。对于基于体素（SPM）的分析，校正整体VT值对于证明[11 C]DPN VT的局灶性发作后增加至关重要。这项研究提供了进一步的直接人体体内证据，表明癫痫发作后TLE中阿片受体可用性发生了变化，包括在没有PVE校正的情况下不明显的变化。去噪、分辨率恢复和精确的解剖分割可以从PET研究中提取有价值的信息，而这些信息在传统的后处理过程中会被遗漏。
Previous positron emission tomography (PET) studies in refractory temporal lobe epilepsy (TLE) using the non-selective opioid receptor antagonist [11C]diprenorphine (DPN) did not detect any changes in mesial temporal structures, despite known involvement of the hippocampus in seizure generation. Normal binding in smaller hippocampi is suggestive of increased receptor concentration in the remaining grey matter. Correction for partial-volume effect (PVE) has not been used in previous DPN PET studies. Here, we present PVE-corrected DPN-PET data quantifying post-ictal and interictal opioid receptor availability in humans with mTLE. Eight paired datasets of post-ictal and interictal DPN PET scans and eleven test/retest control datasets were available from a previously published study on opioid receptor changes in TLE following seizures (Hammers et al., 2007a). Five of the eight participants with TLE had documented hippocampal sclerosis. Data were re-analyzed using regions of interest and a novel PVE correction method (structural functional synergistic-resolution recovery (SFS-RR); (Shidahara et al., 2012)). Data were denoised, followed by application of SFS-RR, with anatomical information derived via precise anatomical segmentation of the participants' MRI (MAPER; (Heckemann et al., 2010)). [11C]diprenorphine volume-of-distribution (VT) was quantified in six regions of interest. Post-ictal increases were observed in the ipsilateral fusiform gyri and lateral temporal pole. A novel finding was a post-ictal increase in [11C]DPN VTrelative to the interictal state in the ipsilateral parahippocampal gyrus, not observed in uncorrected datasets. As for voxel-based (SPM) analyses, correction for global VTvalues was essential in order to demonstrate focal post-ictal increases in [11C]DPN VT. This study provides further direct human in vivo evidence for changes in opioid receptor availability in TLE following seizures, including changes that were not evident without PVE correction. Denoising, resolution recovery and precise anatomical segmentation can extract valuable information from PET studies that would be missed with conventional post-processing procedures.