Cancer's Fuel Choice: New Flavors for a Picky Eater.
Cancer's Fuel Choice: New Flavors for a Picky Eater.
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DOI：
10.1016/j.molcel.2015.10.018
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发表时间：
2015-11-19
期刊：
影响因子：
16
通讯作者：
Cantley LC
中科院分区：
文献类型：
--
作者：
DeNicola GM;Cantley LC
1924年，奥托·瓦尔堡发现癌细胞在充足的氧气存在下表现出高速率的糖酵解，这一过程被称为有氧糖酵解。从那时起，我们已经大大提高了我们对癌症燃料选择的理解，以满足他们对能量和生物合成前体的生产需求。在这篇综述中，我们将讨论癌细胞的首选营养素以及如何利用它们来满足其生物能量和生物合成需求。此外，我们将描述细胞的内在和外在因素，如癌基因突变，营养和氧气的可用性和其他微环境因素如何影响燃料的选择。
Otto Warburg discovered that cancer cells exhibit a high rate of glycolysis in the presence of ample oxygen, a process termed aerobic glycolysis, in 1924. Since then we have significantly advanced our understanding of cancers’ fuel choice to meet their demands for energy and for the production of biosynthetic precursors. In this review, we will discuss the preferred nutrients of cancer cells and how they are utilized to satisfy their bioenergetic and biosynthetic needs. In addition, we will describe how cell intrinsic and extrinsic factors such as oncogene mutations, nutrient and oxygen availability and other microenvironmental factors influence fuel choice.