Inflammatory bowel disease in African-American children living in Georgia
Inflammatory bowel disease in African-American children living in Georgia
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DOI：
10.1016/s0022-3476(98)70187-8
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发表时间：
1998-07-01
影响因子：
5.1
通讯作者：
Gold, BD
中科院分区：
文献类型：
--
作者：
Ogunbi, SO;Ransom, JA;Gold, BD
我们描述了非裔美国儿童与非裔美国儿童炎症性肠病（IBD）的临床特征。我们发现172名患有IBD的儿童；49名（29%）是非裔美国人。非裔美国儿童IBD诊断前的中位症状持续时间（6个月）短于非裔美国儿童（10个月）。在这两个种族中，最常见的症状是便血（溃疡性结肠炎）和腹痛（克罗恩病）。估计非裔美国人克罗恩病的发病率在每10万人中7至12人之间，而在10年的研究中，溃疡性结肠炎患者的发病率在每10万人中5至7人之间。我们的初步研究表明，IBD在非裔美国儿童中可能比以前报道的更常见。基于人群的前瞻性研究将有助于确定与种族相关的遗传因素是否与IBD相关。
We describe the clinical characteristics of inflammatory bowel disease (IBD) in African-American compared with non-African-American children. We identified 172 children with IBD; forty-nine (29%) were African-American. Median symptom duration before IBD diagnosis in African-American children (6 months) was shorter than that of non-African-American children (10 months). The most frequent presenting symptom was hematochezia (ulcerative colitis) and abdominal pain (Crohn's disease) in both racial groups. The estimated incidence of Crohn's disease in African-Americans ranged from 7 per 100,000 to 12 per 100,000, whereas the observed incidence in those with ulcerative colitis was between 5 and 7 per 100,000 during the 10 years of the study. Our pilot study suggests that IBD may be more common in African-American children than previously reported. Prospective population-based studies would be useful to determine whether inheritable factors linked with ethnicity are associated with IBD.