How yeast cells synchronize their glycolytic oscillations: A perturbation analytic treatment
How yeast cells synchronize their glycolytic oscillations: A perturbation analytic treatment
复制标题
DOI：
10.1016/s0006-3495(00)76667-7
复制
发表时间：
2000-03-01
影响因子：
3.4
通讯作者：
Westerhoff, HV
中科院分区：
文献类型：
--
作者：
Bier, M;Bakker, BM;Westerhoff, HV
在所有从糖酵解获得能量的生命形式中，酵母细胞是最基本的。在某些条件下，酵母细胞中糖酵解中间产物的浓度可以振荡。悬浮液中的单个酵母细胞可以使它们的振荡同步，从而彼此同步。虽然糖酵解振荡起源于糖酵解链的上部，但这种同步中的信号剂似乎是乙醛，一种位于糖酵解链厌氧部分底部的膜渗透代谢物。在这里，我们解决的问题，如何远离起搏起源的振荡代谢物仍然可以控制同步。我们提出了一个定量模型的糖酵解振荡和同步的化学动力学。我们表明，在本质上，常见的乙醛浓度可以建模为一个小扰动的“起搏器”的影响，在同一悬浮液中的细胞的振荡周期确实是这样的同步发展。
Of all the lifeforms that obtain their energy from glycolysis,yeast cells are among the most basic. Under certain conditions the concentrations of the glycolytic intermediates in yeast cells can oscillate. Individual yeast cells in a suspension can synchronize their oscillations to get in phase with each other. Although the glycolytic oscillations originate in the upper part of:the glycolytic chain, the signaling agent in this synchronization appears to be acetaldehyde, a membrane-permeating metabolite at the bottom of the anaerobic part of the glycolytic chain. Here we address the issue of how a metabolite remote from the pacemaking origin of the oscillation may nevertheless control the synchronization. We present a quantitative model for glycolytic oscillations and their synchronization in terms of chemical kinetics. We show that, in essence, the common acetaldehyde concentration can be modeled as a small perturbation on the "pacemaker" whose effect on the period of the oscillations of cells in the same suspension is indeed such that a synchronization develops.