Dietary patterns and ethnicity are associated with distinct plasma proteomic groups
Dietary patterns and ethnicity are associated with distinct plasma proteomic groups
复制标题
DOI：
10.3945/ajcn.111.022657
复制
发表时间：
2012-02-01
影响因子：
7.1
通讯作者：
El-Sohemy, Ahmed
中科院分区：
文献类型：
--
作者：
Garcia-Bailo, Bibiana;Brenner, Darren R.;El-Sohemy, Ahmed
背景：高丰度血浆蛋白参与疾病相关途径，可用于营养和疾病状态的诊断。然而，我们对来自不同民族文化群体和不同饮食习惯的个体之间许多血浆蛋白浓度如何变化知之甚少。目的：我们在多伦多营养基因组学和健康研究中探讨了血浆蛋白质组、饮食模式和种族之间的关联，这是一个由健康年轻人组成的不同种族群体。设计：通过液相色谱/多重反应监测-质谱法同时测量 1090 名个体中 54 种高丰度血浆蛋白的浓度。主成分分析用于鉴定血浆蛋白质组。线性回归用于研究蛋白质组与先前确定的饮食模式（西方、谨慎、东方）之间的关系。使用一般线性模型测试民族文化群体之间个体蛋白质浓度的差异。结果：鉴定了代表蛋白质组群体的四个独立主成分。主要成分 1 和 2 包括来自多种途径的蛋白质。成分 3 是炎症，成分 4 包括凝血级联蛋白。东亚人和南亚人的第 1 部分得分较低，而东亚人的第 2 部分得分较高。南亚人的第 3 部分的平均得分较高。不同民族文化群体的个体蛋白质浓度也存在差异。主成分 I 与西方饮食模式呈正相关，与东方饮食模式呈负相关。成分 3 与东方模式呈正相关。结论：具有不同饮食习惯的不同民族文化群体的年轻人之间的血浆蛋白质组有所不同。这些差异可能部分解释了晚年心脏代谢疾病发生率不同的原因。美国临床营养杂志 2012；95：352-61。
Background: High-abundance plasma proteins are involved in disease-associated pathways and are useful in the diagnosis of nutritional and disease states. However, little is known about how concentrations of many plasma proteins vary between individuals from different ethnocultural groups with different dietary habits.Objective: We explored the association between plasma proteomic groups, dietary patterns, and ethnicity in the Toronto Nutrigenomics and Health Study, an ethnically diverse population of healthy young adults.Design: Concentrations of 54 high-abundance plasma proteins were measured simultaneously by liquid chromatography/multiple-reaction monitoring-mass spectrometry in 1090 individuals. Principal components analysis was used to identify plasma proteomic groups. Linear regression was used to investigate relations between proteomic groups and previously identified dietary patterns (Western, prudent, Eastern). Differences in individual protein concentrations between ethnocultural groups were tested by using general linear models.Results: Four independent principal components representative of proteomic groups were identified. Principal components 1 and 2 included proteins from multiple pathways. Component 3 was inflammatory, and component 4 included coagulation cascade proteins. East Asians and South Asians had lower component 1 scores, and East Asians had higher component 2 scores. South Asians had higher average scores for component 3. Individual protein concentrations also varied across ethnocultural groups. Principal component I was positively associated with the Western dietary pattern and inversely associated with the Eastern pattern. Component 3 was positively associated with the Eastern pattern.Conclusions: Plasma proteomic groups differ between young adults of diverse ethnocultural groups with different dietary habits. These differences may partly account for different rates of cardiometabolic disease later in life. Am J Clin Nutr 2012;95:352-61.